TY - JOUR
T1 - Synthesis, Characterization, and Investigation of the Antimicrobial Activity of Cetylpyridinium Tetrachlorozincate
AU - Dubovoy, Viktor
AU - Nawrocki, Shiri
AU - Verma, Gaurav
AU - Wojtas, Lukasz
AU - Desai, Primit
AU - Al-Tameemi, Hassan
AU - Brinzari, Tatiana V.
AU - Stranick, Michael
AU - Chen, Dailin
AU - Xu, Shaopeng
AU - Ma, Shengqian
AU - Boyd, Jeffrey M.
AU - Asefa, Tewodros
AU - Pan, Long
N1 - Funding Information:
The authors would like to thank Dr. Thomas Emge and Dr. Chi-yuan Cheng for their assistance in X-ray diffraction and nuclear magnetic resonance, respectively. The Boyd lab is funded by NIAID award 1R01AI139100-01 from the National Institutes of Health.
Publisher Copyright:
© 2020 American Chemical Society.
PY - 2020/5/12
Y1 - 2020/5/12
N2 - Cetylpyridinium tetrachlorozincate (referred to herein as (CP)2ZnCl4) was synthesized and its solid-state structure was elucidated via single-crystal X-ray diffraction (SC-XRD), revealing a stoichiometry of C42H76Cl4N2Zn with two cetylpyridinium (CP) cations per [ZnCl4]2- tetrahedra. Crystal structures at 100 and 298 K exhibited a zig-zag pattern with alternating alkyl chains and zinc units. The material showed potential for application as a broad-spectrum antimicrobial agent, to reduce volatile sulfur compounds (VSCs) generated by bacteria, and in the fabrication of advanced functional materials. Minimum inhibitory concentration (MIC) of (CP)2ZnCl4 was 60, 6, and 6 μg mL-1 for Salmonella enterica, Staphylococcus aureus, and Streptococcus mutans, respectively. The MIC values of (CP)2ZnCl4 were comparable to that of pure cetylpyridinium chloride (CPC), despite the fact that approximately 16% of the bactericidal CPC is replaced with bacteriostatic ZnCl2 in the structure. A modified layer-by-layer deposition technique was implemented to synthesize mesoporous silica (i.e., SBA-15) loaded with approximately 9.0 wt % CPC and 8.9 wt % Zn.
AB - Cetylpyridinium tetrachlorozincate (referred to herein as (CP)2ZnCl4) was synthesized and its solid-state structure was elucidated via single-crystal X-ray diffraction (SC-XRD), revealing a stoichiometry of C42H76Cl4N2Zn with two cetylpyridinium (CP) cations per [ZnCl4]2- tetrahedra. Crystal structures at 100 and 298 K exhibited a zig-zag pattern with alternating alkyl chains and zinc units. The material showed potential for application as a broad-spectrum antimicrobial agent, to reduce volatile sulfur compounds (VSCs) generated by bacteria, and in the fabrication of advanced functional materials. Minimum inhibitory concentration (MIC) of (CP)2ZnCl4 was 60, 6, and 6 μg mL-1 for Salmonella enterica, Staphylococcus aureus, and Streptococcus mutans, respectively. The MIC values of (CP)2ZnCl4 were comparable to that of pure cetylpyridinium chloride (CPC), despite the fact that approximately 16% of the bactericidal CPC is replaced with bacteriostatic ZnCl2 in the structure. A modified layer-by-layer deposition technique was implemented to synthesize mesoporous silica (i.e., SBA-15) loaded with approximately 9.0 wt % CPC and 8.9 wt % Zn.
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U2 - 10.1021/acsomega.0c00131
DO - 10.1021/acsomega.0c00131
M3 - Article
AN - SCOPUS:85097837927
SN - 2470-1343
VL - 5
SP - 10359
EP - 10365
JO - ACS Omega
JF - ACS Omega
IS - 18
ER -