Synthesis of bicyclic aryl thiazolines with selective anti-proliferative effects on human cancer cell lines

Rakesh K. Singh, Thilo S. Lange, Kyu K. Kim, Ajay P. Singh, Russell Hopson, Nicholi Vorsa, Laurent Brard

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The novel synthesis of aryl thiazolines (ATZ) is described and structures established by COSY, HSQC, HMBC and NOESY experiments. Compounds DCL-ATZ and Me-ATZ displayed cytotoxic activities against a neuroblastoma, a platinum-resistant ovarian adenocarcinoma and a prostate adenocarcinoma cell line. Me-ATZ displayed differential antiproliferative effects.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalLetters in Organic Chemistry
Volume5
Issue number2
DOIs
StatePublished - Mar 2008

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry

Keywords

  • Cytotoxicity
  • Eschenmoser
  • Neuroblastoma
  • Ovarian cancer
  • Thiazolines

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