Synthesis of biotinylated c-di-gmp and c-di-amp using click conjugation

Barbara L. Gaffney; Nicholas D. Stebbins; Roger A. Jones

doi:10.1080/15257770.2012.748196

Synthesis of biotinylated c-di-gmp and c-di-amp using click conjugation

Barbara L. Gaffney, Nicholas D. Stebbins, Roger A. Jones

School of Arts and Sciences, Chemistry & Chemical Biology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The biotinylated c-di-GMP and c-di-AMP conjugates 10a/b were synthesized by a straightforward set of procedures from standard, commercially available phosphoramidites. Their availability should allow isolation and characterization of new protein and RNA receptors for these key bacterial signaling molecules.

Original language	English (US)
Pages (from-to)	1-16
Number of pages	16
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	32
Issue number	1
DOIs	https://doi.org/10.1080/15257770.2012.748196
State	Published - Jan 1 2013

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Genetics

Keywords

Bioconjugates
c-di-AMP analogs
c-di-GMP analogs

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10.1080/15257770.2012.748196

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abstract = "The biotinylated c-di-GMP and c-di-AMP conjugates 10a/b were synthesized by a straightforward set of procedures from standard, commercially available phosphoramidites. Their availability should allow isolation and characterization of new protein and RNA receptors for these key bacterial signaling molecules.",

keywords = "Bioconjugates, c-di-AMP analogs, c-di-GMP analogs",

author = "Gaffney, {Barbara L.} and Stebbins, {Nicholas D.} and Jones, {Roger A.}",

note = "Funding Information: Received 21 October 2012; accepted 6 November 2012. This work was supported by NIH grant GM79760. Address correspondence to Roger A. Jones, Chemistry and Chemical Biology, 610 Taylor Road, Piscataway, NJ 08854, USA. E-mail: r.jones@rutgers.edu",

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AU - Gaffney, Barbara L.

AU - Stebbins, Nicholas D.

AU - Jones, Roger A.

N1 - Funding Information: Received 21 October 2012; accepted 6 November 2012. This work was supported by NIH grant GM79760. Address correspondence to Roger A. Jones, Chemistry and Chemical Biology, 610 Taylor Road, Piscataway, NJ 08854, USA. E-mail: r.jones@rutgers.edu

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KW - Bioconjugates

KW - c-di-AMP analogs

KW - c-di-GMP analogs

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Synthesis of biotinylated c-di-gmp and c-di-amp using click conjugation

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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