Synthesis of biotinylated c-di-gmp and c-di-amp using click conjugation

Barbara L. Gaffney, Nicholas D. Stebbins, Roger A. Jones

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The biotinylated c-di-GMP and c-di-AMP conjugates 10a/b were synthesized by a straightforward set of procedures from standard, commercially available phosphoramidites. Their availability should allow isolation and characterization of new protein and RNA receptors for these key bacterial signaling molecules.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalNucleosides, Nucleotides and Nucleic Acids
Issue number1
StatePublished - Jan 1 2013

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Genetics


  • Bioconjugates
  • c-di-AMP analogs
  • c-di-GMP analogs


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