Synthesis of ethyl N-(diphenyl)methyl-1,2,3,4- tetrahydroisoquinoline-3-carboxylates

Eugene A. Mash; Lawrence J. Williams; Steven S. Pfeiffer

doi:10.1016/S0040-4039(97)01668-7

Synthesis of ethyl N-(diphenyl)methyl-1,2,3,4- tetrahydroisoquinoline-3-carboxylates

Eugene A. Mash, Lawrence J. Williams, Steven S. Pfeiffer

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A concise method for the synthesis of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives from α,α'-dibromo-o-xylenes via sequential C-alkylation and N-alkylation of a glycine anion is described.

Original language	English (US)
Pages (from-to)	6977-6980
Number of pages	4
Journal	Tetrahedron Letters
Volume	38
Issue number	40
DOIs	https://doi.org/10.1016/S0040-4039(97)01668-7
State	Published - Oct 6 1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(97)01668-7

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title = "Synthesis of ethyl N-(diphenyl)methyl-1,2,3,4- tetrahydroisoquinoline-3-carboxylates",

abstract = "A concise method for the synthesis of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives from α,α'-dibromo-o-xylenes via sequential C-alkylation and N-alkylation of a glycine anion is described.",

author = "Mash, {Eugene A.} and Williams, {Lawrence J.} and Pfeiffer, {Steven S.}",

year = "1997",

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T1 - Synthesis of ethyl N-(diphenyl)methyl-1,2,3,4- tetrahydroisoquinoline-3-carboxylates

AU - Mash, Eugene A.

AU - Williams, Lawrence J.

AU - Pfeiffer, Steven S.

PY - 1997/10/6

Y1 - 1997/10/6

N2 - A concise method for the synthesis of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives from α,α'-dibromo-o-xylenes via sequential C-alkylation and N-alkylation of a glycine anion is described.

AB - A concise method for the synthesis of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives from α,α'-dibromo-o-xylenes via sequential C-alkylation and N-alkylation of a glycine anion is described.

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U2 - 10.1016/S0040-4039(97)01668-7

DO - 10.1016/S0040-4039(97)01668-7

M3 - Article

AN - SCOPUS:0030843899

SN - 0040-4039

VL - 38

SP - 6977

EP - 6980

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 40

ER -

Synthesis of ethyl N-(diphenyl)methyl-1,2,3,4- tetrahydroisoquinoline-3-carboxylates

Abstract

All Science Journal Classification (ASJC) codes

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