Synthesis of the Monofluoro Ketone Peptide Isostere

Garry S. Garrett, Thomas J. Emge, Susannie C. Lee, Elaine M. Fischer, Karyn Dyehouse, John M. McIver

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

A synthetic method for the construction of monofluoro ketone peptide isosteres has been realized. The methodology has been employed in a synthesis of the fluoro ketone replacement for the natural substrate for D,D-carboxypeptidase-transpeptidase.

Original languageEnglish (US)
Pages (from-to)4823-4826
Number of pages4
JournalJournal of Organic Chemistry
Volume56
Issue number16
DOIs
StatePublished - Aug 1 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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