Synthesis of tyrocidine a: Use of oxime resin for peptide chain assembly and cyclization

George Ösapay, Adam Profit, John W. Taylor

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Application of the Kaiser oxime resin to the synthesis of the thirty-membered ring cyclo-decapeptide Tyrocidine A (TA) is described. Assembly of the linear peptide chain and its subsequent cyclization with concomitant cleavage off the solid support were both achieved in high yield (73.2 % and 55 %).

Original languageEnglish (US)
Pages (from-to)6121-6124
Number of pages4
JournalTetrahedron Letters
Volume31
Issue number43
DOIs
StatePublished - 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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