Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions

Christophe D. Guillon, Yi Hua Jan, Natalie Foster, Joel Ressner, Diane E. Heck, Jeffrey D. Laskin, Ned D. Heindel

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.

Original languageEnglish (US)
Pages (from-to)619-622
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume29
Issue number4
DOIs
StatePublished - Feb 15 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Keywords

  • 8-MOP
  • 8-Methoxypsoralen
  • Dark-reaction toxicity
  • Keratinocytes
  • PAM212
  • Phototoxicity

Fingerprint Dive into the research topics of 'Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions'. Together they form a unique fingerprint.

  • Cite this