Systemic administration of a dopamine, but not a serotonin or norepinephrine, transporter inhibitor reinstates cocaine seeking in the rat

Heath D. Schmidt, R. Christopher Pierce

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Reinstatement of cocaine-seeking behavior can be elicited by a systemic priming injection of cocaine or a non-selective biogenic amine transporter inhibitor. In order to determine which biogenic amine is responsible for this effect, selective dopamine (GBR 12909), serotonin (fluoxetine) or norepinephrine (nisoxetine) transporter inhibitors were systemically administered in order to assess their ability to induce cocaine seeking in rats. Administration of GBR 12909, but not nisoxetine or fluoxetine, dose-dependently reinstated cocaine seeking in rats. Furthermore, administration of the non-selective dopamine receptor antagonist flupenthixol into the nucleus accumbens shell attenuated GBR 12909-induced reinstatement of cocaine seeking. These results suggest that increases in extracellular concentrations of dopamine, specifically in the nucleus accumbens shell, are primarily responsible for promoting cocaine priming-induced reinstatement of drug seeking in rats.

Original languageEnglish (US)
Pages (from-to)189-194
Number of pages6
JournalBehavioural Brain Research
Volume175
Issue number1
DOIs
StatePublished - Nov 25 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Keywords

  • Addiction
  • Dopamine transporter
  • Monoamine
  • Norepinephrine transporter
  • Psychostimulant
  • Reinstatement
  • Relapse
  • Self-administration
  • Serotonin transporter

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