TY - JOUR
T1 - Systemic Methotrexate Toxicity
T2 - A Pharmacological Study of Its Occurrence After Intrathecal Administration in a Patient With Renal Failure
AU - Cadman, C.
AU - Lundberg, Walter B.
AU - Bertino, Joseph R.
PY - 1976/11
Y1 - 1976/11
N2 - Methotrexate pharmacokinetic studies, performed on a patient with renal impairment who had toxic effects following 20 mg/sq m of intrathecally administered methotrexate, demonstrated prolonged serum concentrations of the drug, which accounted for the condition. After the return of normal renal function, pharmacokinetic studies were repeated following the same dose and route of administration of methotrexate. On this occasion there was a rapid clearance of serum methotrexate below toxic levels.
AB - Methotrexate pharmacokinetic studies, performed on a patient with renal impairment who had toxic effects following 20 mg/sq m of intrathecally administered methotrexate, demonstrated prolonged serum concentrations of the drug, which accounted for the condition. After the return of normal renal function, pharmacokinetic studies were repeated following the same dose and route of administration of methotrexate. On this occasion there was a rapid clearance of serum methotrexate below toxic levels.
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U2 - 10.1001/archinte.1976.03630110079020
DO - 10.1001/archinte.1976.03630110079020
M3 - Article
C2 - 990053
AN - SCOPUS:0017160797
SN - 0003-9926
VL - 136
SP - 1321
EP - 1322
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 11
ER -