T cell subsets and disease progression after total lymphoid irradiation in chronic progressive multiple sclerosis

R. Troiano, C. Devereux, J. Oleske, T. Denny, M. Hafstein, G. Zito, C. Rohowski-Kochan, P. C. Dowling, S. D. Cook

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

T lymphocyte subset percentages were determined in 16 total lymphoid irradiation (TLI) treated and 18 sham treated control patients with chronic progressive multiple sclerosis. During the first year after treatment, the ratio of T helper/inducer to T suppressor/cytotoxic cells (Th/Ts ratio) was significantly higher in sham treated multiple sclerosis patients who worsened clinically compared with TLI treated and sham treated multiple sclerosis patients who remained clinically stable. TLI caused a fall in the percentage of T helper cells in treated patients, while the percentage of T suppressor cells remained stable during the first year after treatment. In contrast, the percentage of T suppressor cells fell in sham treated multiple sclerosis patients who worsened clinically.

Original languageEnglish (US)
Pages (from-to)980-983
Number of pages4
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume51
Issue number7
DOIs
StatePublished - 1988

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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