Tachykinins and Hematopoiesis

Katherine Liu, Marianne D. Castillo, Raghav G. Murthy, Nitixa Patel, Pranela Rameshwar

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Originally discovered in the 1930s, tachykinins have been a subject of renewed interest. Antagonists to the tachykinin receptors have shown potential in the treatment of a variety of maladies including neurodegenerative disorders, heart disease, pain perception and malignancies. Tachykinins have been the subject of intense studies due to their impact on hematopoiesis that has significant effects on endothelial tissue and vascular conditions. Hematopoiesis relies on a relatively small subset of bone marrow-resident hematopoietic stem cells. This review discusses the network developed by cytokines and the tachykinins to regulate hematopoiesis. An understanding of tachykinin effect on normal hematopoietic functions and their involvement in hematological disorders could lead to new treatments for bone marrow disorders such as fibrosis, leukemia and anemia.

Original languageEnglish (US)
Pages (from-to)28-34
Number of pages7
JournalClinica Chimica Acta
Volume385
Issue number1-2
DOIs
StatePublished - Oct 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Keywords

  • Bone marrow
  • Hematopoiesis
  • Tachykinins

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