Target specific-trisubstituted pyrrole inhibits Babesia bovis erythrocytic growth

Audrey O.T. Lau, Monica J. Pedroni, Purnima Bhanot

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Babesiosis, a significant veterinary disease and an emerging zoonotic human infection, is caused by certain species of the protozoan parasite, Babesia. Here we report that a trisubstituted pyrrole is a potent inhibitor of Babesia bovis, a bovine parasite. Furthermore, B. bovis expresses the known target of the compound, the cGMP dependent protein kinase. Target conservation and the in vitro efficacy support further investigation of this compound and validation of Babesia cGMP dependent protein kinase as its in vivo target.

Original languageEnglish (US)
Pages (from-to)365-368
Number of pages4
JournalExperimental Parasitology
Issue number3
StatePublished - Mar 2013

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Immunology
  • Infectious Diseases


  • Babesia bovis
  • Intra-erythrocytic growth
  • Trisubstituted pyrrole


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