Targeting airway smooth muscle in airways diseases: An old concept with new twists

Cynthia J. Koziol-White; Gautam Damera; Reynold A. Panettieri

doi:10.1586/ers.11.77

Targeting airway smooth muscle in airways diseases: An old concept with new twists

Cynthia J. Koziol-White, Gautam Damera, Reynold A. Panettieri

SVC Clinical & Translational R

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Airway smooth muscle (ASM) manifests a hyper-responsive phenotype in airway disorders such as asthma. ASM also modulates immune responses by secreting mediators and expressing cell-surface molecules that promote recruitment of inflammatory cells to the lungs. The aim of the current article is to highlight therapeutics that may modulate ASM responses in airway disorders and exacerbations.

Original language	English (US)
Pages (from-to)	767-777
Number of pages	11
Journal	Expert Review of Respiratory Medicine
Volume	5
Issue number	6
DOIs	https://doi.org/10.1586/ers.11.77
State	Published - Dec 2011

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Pulmonary and Respiratory Medicine
Public Health, Environmental and Occupational Health

Keywords

Antibody therapy
Asthma
Bronchial thermoplasty
Exacerbation
Remodeling

Access to Document

10.1586/ers.11.77

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title = "Targeting airway smooth muscle in airways diseases: An old concept with new twists",

abstract = "Airway smooth muscle (ASM) manifests a hyper-responsive phenotype in airway disorders such as asthma. ASM also modulates immune responses by secreting mediators and expressing cell-surface molecules that promote recruitment of inflammatory cells to the lungs. The aim of the current article is to highlight therapeutics that may modulate ASM responses in airway disorders and exacerbations.",

keywords = "Antibody therapy, Asthma, Bronchial thermoplasty, Exacerbation, Remodeling",

author = "Koziol-White, {Cynthia J.} and Gautam Damera and Panettieri, {Reynold A.}",

note = "Funding Information: RA Panettieri Jr is supported by NIH funding grant numbers R01-HL097796, R01-HL077735 and NIEHS: P30-ES013508. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.",

year = "2011",

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doi = "10.1586/ers.11.77",

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T2 - An old concept with new twists

AU - Koziol-White, Cynthia J.

AU - Damera, Gautam

AU - Panettieri, Reynold A.

N1 - Funding Information: RA Panettieri Jr is supported by NIH funding grant numbers R01-HL097796, R01-HL077735 and NIEHS: P30-ES013508. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

PY - 2011/12

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N2 - Airway smooth muscle (ASM) manifests a hyper-responsive phenotype in airway disorders such as asthma. ASM also modulates immune responses by secreting mediators and expressing cell-surface molecules that promote recruitment of inflammatory cells to the lungs. The aim of the current article is to highlight therapeutics that may modulate ASM responses in airway disorders and exacerbations.

AB - Airway smooth muscle (ASM) manifests a hyper-responsive phenotype in airway disorders such as asthma. ASM also modulates immune responses by secreting mediators and expressing cell-surface molecules that promote recruitment of inflammatory cells to the lungs. The aim of the current article is to highlight therapeutics that may modulate ASM responses in airway disorders and exacerbations.

KW - Antibody therapy

KW - Asthma

KW - Bronchial thermoplasty

KW - Exacerbation

KW - Remodeling

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