Targeting airway smooth muscle in airways diseases: An old concept with new twists

Cynthia J. Koziol-White, Gautam Damera, Reynold A. Panettieri

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Airway smooth muscle (ASM) manifests a hyper-responsive phenotype in airway disorders such as asthma. ASM also modulates immune responses by secreting mediators and expressing cell-surface molecules that promote recruitment of inflammatory cells to the lungs. The aim of the current article is to highlight therapeutics that may modulate ASM responses in airway disorders and exacerbations.

Original languageEnglish (US)
Pages (from-to)767-777
Number of pages11
JournalExpert Review of Respiratory Medicine
Volume5
Issue number6
DOIs
StatePublished - Dec 2011

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health

Keywords

  • Antibody therapy
  • Asthma
  • Bronchial thermoplasty
  • Exacerbation
  • Remodeling

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