TY - JOUR
T1 - Targeting vesicles to specific sites on the plasma membrane
T2 - The role of the sec6/8 complex
AU - Hsu, Shu Chan
AU - Hazuka, Christopher D.
AU - Foletti, Davide L.
AU - Scheller, Richard H.
PY - 1999/4/1
Y1 - 1999/4/1
N2 - The delivery of secretory vesicles to appropriate docking and fusion sites on the plasma membrane is crucial for many cellular functions, including formation of synapses, exocytosis of neurotransmitter, establishment and maintenance of cell polarity, cell growth and plasma membrane wound healing. Cell-biological, genetic and biochemical approaches have identified crucial proteins and protein interactions important for vesicle docking and fusion. However, a description of the molecular mechanisms underlying vesicle targeting to specific membrane-fusion sites remains elusive. This review discusses a set of proteins that might direct vesicles to specific domains of the plasma membrane.
AB - The delivery of secretory vesicles to appropriate docking and fusion sites on the plasma membrane is crucial for many cellular functions, including formation of synapses, exocytosis of neurotransmitter, establishment and maintenance of cell polarity, cell growth and plasma membrane wound healing. Cell-biological, genetic and biochemical approaches have identified crucial proteins and protein interactions important for vesicle docking and fusion. However, a description of the molecular mechanisms underlying vesicle targeting to specific membrane-fusion sites remains elusive. This review discusses a set of proteins that might direct vesicles to specific domains of the plasma membrane.
UR - http://www.scopus.com/inward/record.url?scp=0032904433&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032904433&partnerID=8YFLogxK
U2 - 10.1016/S0962-8924(99)01516-0
DO - 10.1016/S0962-8924(99)01516-0
M3 - Review article
C2 - 10203793
AN - SCOPUS:0032904433
SN - 0962-8924
VL - 9
SP - 150
EP - 153
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 4
ER -