Telomere length inversely correlates with pulse pressure and is highly familial

Elisabeth Jeanclos, Nicholas J. Schork, Kirsten O. Kyvik, Masayuki Kimura, Joan H. Skurnick, Abraham Aviv

Research output: Contribution to journalArticlepeer-review

294 Scopus citations

Abstract

There is evidence that telomeres, the ends of chromosomes, serve as clocks that pace cellular aging in vitro and in vitro. In industrialized nations, pulse pressure rises with age, and it might serve as a phenotype of biological aging of the vasculature. We therefore conducted a twin study to investigate the relation between telomere length in white blood cells and pulse pressure while simultaneously assessing the role of genetic factors in determining telomere length. We measured by Southern blot analysis the mean length of the terminal restriction fragments (TRF) in white blood cells of 49 twin pairs from the Danish Twin Register and assessed the relations of blood pressure parameters with TRF. TRF length showed an inverse relation with pulse pressure. Both TRF length and pulse pressure were highly familial. We conclude that telomere length, which is under genetic control, might play a role in mechanisms that regulate pulse pressure, including vascular aging.

Original languageEnglish (US)
Pages (from-to)195-200
Number of pages6
JournalHypertension
Volume36
Issue number2
DOIs
StatePublished - 2000

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Keywords

  • Age
  • Blood pressure
  • Pulse
  • Twins

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