TY - JOUR
T1 - Telomeres and human somatic fitness
AU - Aviv, Abraham
N1 - Funding Information:
ACKNOWLEDGMENT The author’s research on telomeres is supported by National Institutes of Health grants AG021593 and AG020132 and by The Healthcare Foundation of New Jersey.
PY - 2006/8
Y1 - 2006/8
N2 - Mean leukocyte telomere length may be an indicator of biological age, and as such it appears to provide information over and above chronological age of the risk for developing diseases of aging in humans. Here I propose that the mean leukocyte telomere length is an index of "somatic fitness," a concept that breaks down the artificial boundary between aging and diseases of aging. I also propose that, in exceptionally old humans, ultrashort leukocyte telomeres might be a determinant of life span.
AB - Mean leukocyte telomere length may be an indicator of biological age, and as such it appears to provide information over and above chronological age of the risk for developing diseases of aging in humans. Here I propose that the mean leukocyte telomere length is an index of "somatic fitness," a concept that breaks down the artificial boundary between aging and diseases of aging. I also propose that, in exceptionally old humans, ultrashort leukocyte telomeres might be a determinant of life span.
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U2 - 10.1093/gerona/61.8.871
DO - 10.1093/gerona/61.8.871
M3 - Short survey
C2 - 16912107
AN - SCOPUS:33747493496
SN - 1079-5006
VL - 61
SP - 871
EP - 873
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 8
ER -