Telomeres, atherosclerosis, and the hemothelium: The longer view

Abraham Aviv, Daniel Levy

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


The model we propose to explain the links between atherosclerosis and telomere dynamics (birth telomere length and its age-dependent shortening) in leukocytes takes cues from three facts: atherosclerosis is a disease of the vascular endothelium; the hematopoietic system and the vascular endothelium share a common embryonic origin; interindividual variation in leukocyte telomere length (LTL) in the general population has a genetic explanation. The model posits that LTL dynamics mirror telomere dynamics in hematopoietic stem cells (HSCs), where telomere length is an index of HSC reserves. Diminished HSC reserves at birth, their accelerated attrition rate afterward, or both are are reflected in shortened LTL during adulthooda phenomenon that confers increased risk for atherosclerosis. We explain how telomere length in HSCs serves as both a biomarker of atherosclerosis and a determinant of its development. Our model comes down to this proposition: Shortened LTL predicts increased atherosclerotic risk because the injurious component of atherosclerosis exceeds the repair capacity of HSC reserves, which largely depend on HSC telomere length.

Original languageEnglish (US)
Pages (from-to)293-301
Number of pages9
JournalAnnual review of medicine
StatePublished - 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)


  • Aging
  • Birth
  • Endothelial progenitor cells
  • Genes
  • Hematopoietic stem cells


Dive into the research topics of 'Telomeres, atherosclerosis, and the hemothelium: The longer view'. Together they form a unique fingerprint.

Cite this