TY - JOUR
T1 - Telomeres
T2 - The time factor in essential hypertension
AU - Aviv, Abraham
AU - Zahorodny, Walter
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Essential hypertension, particularly systolic hypertension, can be characterized as a disorder of aging. The diverse expressions of this disorder represent the interactions of a genetic script, the environment, chance, and a temporal factor. The temporal factor, namely the telomeres, is biological, intrinsic, and dynamic. Telomere length is heritable, is inversely related to pulse pressure, and can be modified by reactive oxygen species. The incorporation of a temporal factor into models of essential hypertension may provide a heretofore missing link explaining variations in age-dependent increase in pulse pressure.
AB - Essential hypertension, particularly systolic hypertension, can be characterized as a disorder of aging. The diverse expressions of this disorder represent the interactions of a genetic script, the environment, chance, and a temporal factor. The temporal factor, namely the telomeres, is biological, intrinsic, and dynamic. Telomere length is heritable, is inversely related to pulse pressure, and can be modified by reactive oxygen species. The incorporation of a temporal factor into models of essential hypertension may provide a heretofore missing link explaining variations in age-dependent increase in pulse pressure.
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U2 - 10.1007/s11906-001-0075-x
DO - 10.1007/s11906-001-0075-x
M3 - Article
C2 - 11177705
AN - SCOPUS:0035256525
VL - 3
SP - 33
EP - 35
JO - Current Hypertension Reports
JF - Current Hypertension Reports
SN - 1522-6417
IS - 1
ER -