TEMPERATURE DEPENDENCE OF ANISOTONIC NaCl EFFECT ON RADIOSENSITIZATION AND ULTRASTRUCTURE OF V79 CHINESE HAMSTER CELLS.

J. G. Szekely, A. U. Lobreau, E. I. Azzam, T. P. Copps, A. U. Raaphorst

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Abstract

Isodose radiation survival of V79 Chinese hamster cells, pretreated with strongly hypertonic concentrations of NaCl at 22 degree C, or at 37 degree C, has been determined and correlated with ultrastructural changes within the nucleus. After an exposure of less than 10 min to 1. 5 M NaCl, at both temperatures, the cells are radioprotected, but after longer exposures, the cells treated at 37 degree C are radiosensitive, whereas those treated at 22 degree C still show protection. The cells are radiosensitized at both temperatures by pretreatment with 0. 5 M and 0. 05 M NaCl. The ultrastructure of the nucleus observed after the anisotonic treatments suggests that contraction or swelling of chromatin may be associated with the observed variation in radiation sensitivity.

Original languageEnglish (US)
Pages (from-to)2027-2035
Number of pages9
JournalScanning Electron Microscopy
Issue numberpt 4
StatePublished - 1983
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering
  • Biophysics

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