Testicular in vitro conversion of progesterone to testosterone and androstenedione in 17α-hydroxylase deficiency

Ibrahim S. Salti; Hiyam Hajj; Suhayl Dhib-Jalbut

doi:10.1016/0022-4731(82)90115-7

Testicular in vitro conversion of progesterone to testosterone and androstenedione in 17α-hydroxylase deficiency

Ibrahim S. Salti, Hiyam Hajj, Suhayl Dhib-Jalbut

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Incubations of [³H]-progesterone with testicular tissue obtained from a new case of male with 17α-hydroxylase deficiency were performed. The per cent conversion to androstenedione and testosterone was virtually absent when compared to that obtained from an identical incubation performed using testicular tissue from a normal male with cryptochordism. The findings provide an in vitro evidence in support of the existence of 17α-hydroxylase testicular defect in this disorder.

Original language	English (US)
Pages (from-to)	155-157
Number of pages	3
Journal	Journal of Steroid Biochemistry
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/0022-4731(82)90115-7
State	Published - Aug 1982
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Endocrinology

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10.1016/0022-4731(82)90115-7

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@article{8b7c38cbf36442b195e7af280780752c,

title = "Testicular in vitro conversion of progesterone to testosterone and androstenedione in 17α-hydroxylase deficiency",

abstract = "Incubations of [3H]-progesterone with testicular tissue obtained from a new case of male with 17α-hydroxylase deficiency were performed. The per cent conversion to androstenedione and testosterone was virtually absent when compared to that obtained from an identical incubation performed using testicular tissue from a normal male with cryptochordism. The findings provide an in vitro evidence in support of the existence of 17α-hydroxylase testicular defect in this disorder.",

author = "Salti, {Ibrahim S.} and Hiyam Hajj and Suhayl Dhib-Jalbut",

note = "Funding Information: Acknowledgements-Thisw ork was supported by grant No. 18-5208fr om the ResearchC ommittee,F aculty of Medicine.T he authorsa reg ratefutlo Miss AghavnyG uir-agossianf or her help in preparingt his manuscript.",

year = "1982",

month = aug,

doi = "10.1016/0022-4731(82)90115-7",

language = "English (US)",

volume = "17",

pages = "155--157",

journal = "Journal of Steroid Biochemistry",

issn = "0022-4731",

publisher = "Elsevier Ltd",

number = "2",

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TY - JOUR

T1 - Testicular in vitro conversion of progesterone to testosterone and androstenedione in 17α-hydroxylase deficiency

AU - Salti, Ibrahim S.

AU - Hajj, Hiyam

AU - Dhib-Jalbut, Suhayl

N1 - Funding Information: Acknowledgements-Thisw ork was supported by grant No. 18-5208fr om the ResearchC ommittee,F aculty of Medicine.T he authorsa reg ratefutlo Miss AghavnyG uir-agossianf or her help in preparingt his manuscript.

PY - 1982/8

Y1 - 1982/8

N2 - Incubations of [3H]-progesterone with testicular tissue obtained from a new case of male with 17α-hydroxylase deficiency were performed. The per cent conversion to androstenedione and testosterone was virtually absent when compared to that obtained from an identical incubation performed using testicular tissue from a normal male with cryptochordism. The findings provide an in vitro evidence in support of the existence of 17α-hydroxylase testicular defect in this disorder.

AB - Incubations of [3H]-progesterone with testicular tissue obtained from a new case of male with 17α-hydroxylase deficiency were performed. The per cent conversion to androstenedione and testosterone was virtually absent when compared to that obtained from an identical incubation performed using testicular tissue from a normal male with cryptochordism. The findings provide an in vitro evidence in support of the existence of 17α-hydroxylase testicular defect in this disorder.

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U2 - 10.1016/0022-4731(82)90115-7

DO - 10.1016/0022-4731(82)90115-7

M3 - Article

C2 - 6981031

AN - SCOPUS:0020326259

SN - 0022-4731

VL - 17

SP - 155

EP - 157

JO - Journal of Steroid Biochemistry

JF - Journal of Steroid Biochemistry

IS - 2

ER -

Testicular in vitro conversion of progesterone to testosterone and androstenedione in 17α-hydroxylase deficiency

Abstract

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