TY - JOUR
T1 - Tetraplex formation of a guanine-containing nonameric DNA fragment
AU - Renzhe, Jin
AU - Breslauer, Kenneth J.
AU - Jones, Roger A.
AU - Gaffney, Barbara L.
PY - 1990
Y1 - 1990
N2 - A combination of spectroscopic and calorimetric techniques has been used to characterize the structures formed by a family of short, guanine-containing DNA single strands of the form d[GGTTXTTGG], X=A, C, G, T. In 1 molar NaCl at low temperatures, these molecules do not behave like single strands, but rather exhibit properties consistent with tetraplex formation. The standard state enthalpies, entropies, and free energies for formation of each tetraplex have been measured, as have preliminary nuclear magnetic resonance (NMR) spectra. In 1 molar KCl, the melting behavior of the structure or structures is more complex than in 1 molar NaCl. This observation may be related to the recently proposed "sodium-potassium switch".
AB - A combination of spectroscopic and calorimetric techniques has been used to characterize the structures formed by a family of short, guanine-containing DNA single strands of the form d[GGTTXTTGG], X=A, C, G, T. In 1 molar NaCl at low temperatures, these molecules do not behave like single strands, but rather exhibit properties consistent with tetraplex formation. The standard state enthalpies, entropies, and free energies for formation of each tetraplex have been measured, as have preliminary nuclear magnetic resonance (NMR) spectra. In 1 molar KCl, the melting behavior of the structure or structures is more complex than in 1 molar NaCl. This observation may be related to the recently proposed "sodium-potassium switch".
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U2 - 10.1126/science.2237404
DO - 10.1126/science.2237404
M3 - Article
C2 - 2237404
AN - SCOPUS:0025202253
SN - 0036-8075
VL - 250
SP - 543
EP - 546
JO - Science
JF - Science
IS - 4980
ER -