Th1/Th2 effector choice in parasitic infection: Decision making by committee

Dragana Jankovic, Alan Sher, George Yap

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations


Parasitic infections frequently result in highly polarized CD4+ T cell responses characterized by dominant Th1 or Th2 cytokine production profiles. Although previously thought to be strictly dependent on signaling by the differentiative cytokines, IL-12 and IL-4, recent data indicate that this polarization may be primarily decided instead by a series of different factors intrinsic to the pathogen-antigen-presenting-cell interaction that influence T cell priming.

Original languageEnglish (US)
Pages (from-to)403-409
Number of pages7
JournalCurrent Opinion in Immunology
Issue number4
StatePublished - Aug 1 2001

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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