Abstract
Parasitic infections frequently result in highly polarized CD4+ T cell responses characterized by dominant Th1 or Th2 cytokine production profiles. Although previously thought to be strictly dependent on signaling by the differentiative cytokines, IL-12 and IL-4, recent data indicate that this polarization may be primarily decided instead by a series of different factors intrinsic to the pathogen-antigen-presenting-cell interaction that influence T cell priming.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 403-409 |
| Number of pages | 7 |
| Journal | Current Opinion in Immunology |
| Volume | 13 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 1 2001 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
Cite this
}
Th1/Th2 effector choice in parasitic infection : Decision making by committee. / Jankovic, Dragana; Sher, Alan; Yap, George.
In: Current Opinion in Immunology, Vol. 13, No. 4, 01.08.2001, p. 403-409.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Th1/Th2 effector choice in parasitic infection
T2 - Decision making by committee
AU - Jankovic, Dragana
AU - Sher, Alan
AU - Yap, George
PY - 2001/8/1
Y1 - 2001/8/1
N2 - Parasitic infections frequently result in highly polarized CD4+ T cell responses characterized by dominant Th1 or Th2 cytokine production profiles. Although previously thought to be strictly dependent on signaling by the differentiative cytokines, IL-12 and IL-4, recent data indicate that this polarization may be primarily decided instead by a series of different factors intrinsic to the pathogen-antigen-presenting-cell interaction that influence T cell priming.
AB - Parasitic infections frequently result in highly polarized CD4+ T cell responses characterized by dominant Th1 or Th2 cytokine production profiles. Although previously thought to be strictly dependent on signaling by the differentiative cytokines, IL-12 and IL-4, recent data indicate that this polarization may be primarily decided instead by a series of different factors intrinsic to the pathogen-antigen-presenting-cell interaction that influence T cell priming.
UR - http://www.scopus.com/inward/record.url?scp=0035423779&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035423779&partnerID=8YFLogxK
U2 - 10.1016/S0952-7915(00)00234-X
DO - 10.1016/S0952-7915(00)00234-X
M3 - Review article
VL - 13
SP - 403
EP - 409
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
SN - 0952-7915
IS - 4
ER -