Th1/Th2 effector choice in parasitic infection

Decision making by committee

Dragana Jankovic, Alan Sher, George Yap

Research output: Contribution to journalReview article

65 Citations (Scopus)

Abstract

Parasitic infections frequently result in highly polarized CD4+ T cell responses characterized by dominant Th1 or Th2 cytokine production profiles. Although previously thought to be strictly dependent on signaling by the differentiative cytokines, IL-12 and IL-4, recent data indicate that this polarization may be primarily decided instead by a series of different factors intrinsic to the pathogen-antigen-presenting-cell interaction that influence T cell priming.

Original languageEnglish (US)
Pages (from-to)403-409
Number of pages7
JournalCurrent Opinion in Immunology
Volume13
Issue number4
DOIs
StatePublished - Aug 1 2001
Externally publishedYes

Fingerprint

Parasitic Diseases
Decision Making
Cytokines
T-Lymphocytes
Intrinsic Factor
Antigen-Presenting Cells
Interleukin-12
Cell Communication
Interleukin-4

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

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Th1/Th2 effector choice in parasitic infection : Decision making by committee. / Jankovic, Dragana; Sher, Alan; Yap, George.

In: Current Opinion in Immunology, Vol. 13, No. 4, 01.08.2001, p. 403-409.

Research output: Contribution to journalReview article

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AU - Yap, George

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