TY - JOUR
T1 - Th1/Th2 effector choice in parasitic infection
T2 - Decision making by committee
AU - Jankovic, Dragana
AU - Sher, Alan
AU - Yap, George
PY - 2001/8/1
Y1 - 2001/8/1
N2 - Parasitic infections frequently result in highly polarized CD4+ T cell responses characterized by dominant Th1 or Th2 cytokine production profiles. Although previously thought to be strictly dependent on signaling by the differentiative cytokines, IL-12 and IL-4, recent data indicate that this polarization may be primarily decided instead by a series of different factors intrinsic to the pathogen-antigen-presenting-cell interaction that influence T cell priming.
AB - Parasitic infections frequently result in highly polarized CD4+ T cell responses characterized by dominant Th1 or Th2 cytokine production profiles. Although previously thought to be strictly dependent on signaling by the differentiative cytokines, IL-12 and IL-4, recent data indicate that this polarization may be primarily decided instead by a series of different factors intrinsic to the pathogen-antigen-presenting-cell interaction that influence T cell priming.
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U2 - 10.1016/S0952-7915(00)00234-X
DO - 10.1016/S0952-7915(00)00234-X
M3 - Review article
C2 - 11498295
AN - SCOPUS:0035423779
VL - 13
SP - 403
EP - 409
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
SN - 0952-7915
IS - 4
ER -