Thalidomide and its dermatologic uses

Kapila V. Paghdal, Robert Schwartz

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Thalidomide is a beneficial agent for treating a variety of refractory dermatologic disorders including erythema nodosom leprosum, lupus erythematosus, prurigo nodularis, actinic prurigo, pyoderma gangrenosum and aphthous stomatitis. Two thalidomide analogues, lenalidomide and CC-4047, are considerably more potent with decreased side effects when compared to thalidomide. They are currently undergoing trials and show promise, as they have increased immunomodulatory and anti-angiogenic activity. This category of medication and its use will be reviewed.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalActa Dermatovenerologica Croatica
Volume15
Issue number1
StatePublished - 2007

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Infectious Diseases

Keywords

  • Erythema nodosom leprosum
  • Immunomodulation
  • Teratogenicity
  • Thalidomide

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