The α-synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: A study of 230 European cases

Jenny Vaughan, Alexandra Durr, Johann Tassin, Benjamin Bereznai, Thomas Gasser, Vincenzo Bonifati, Giuseppe De Michele, Edito Fabrizio, Gianpiero Volpe, O. Bandmann, William Johnson, Lawrence Golbe, Monique Breteler, Giuseppe Meco, Yves Agid, Alexis Brice, C. David Marsden, Nicholas W. Wood

Research output: Contribution to journalArticlepeer-review

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Abstract

We report the results of a screen of 230 European familial index cases of Parkinson's disease for the recently described Ala53Thr mutation in the α-synuclein gene in an autosomal dominant Parkinson's disease kindred. No mutations were found from this broad white population, and we therefore conclude that although of great interest, this mutation is a very rare cause of familial Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)270-273
Number of pages4
JournalAnnals of Neurology
Volume44
Issue number2
DOIs
StatePublished - Aug 1 1998

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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