During 1984 several important developments advanced our understanding of the acquired immunodeficiency syndrome (AIDS). A retrovirus known as human T-cell leukemia (lymphotropic) virus type III (HTLV-III),1 also called lymphadenopathy-associated virus, was identified as the probable cause of AIDS.2 AIDS-associated retrovirus3 is also probably the same agent. An enzyme-linked immunosorbent assay (ELISA) has been developed to detect antibodies to HTLV-III,4 thereby providing an indicator of whether or not a person has been exposed to the virus. Clinical researchers have identified various therapeutic agents that appear to inhibit viral replication in vitro.5,6 Although the ultimate goal of all these research activities is.
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