The Application of Antibiotic Bonding to the Treatment of Established Vascular Prosthetic Infection

Ralph S. Greco, Stanley Z. Trooskin, Anthony P. Donetz, Richard A. Harvey

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

• We used surfactant-mediated antibiotic bonding to treat established vascular prosthetic infections in an animal model. The infrarenal aorta of dogs was replaced with a polytef (PTFE) graft locally contaminated with Staphylococcus aureus. Infected grafts were then replaced with control polytef or polytef bonded with benzylkonium chloride and penicillin G tagged with radioactive carbon, or polytef bonded with tridodecylmethylammonium chloride and penicillin G tagged with radioactive carbon. Both types of antibiotic-bonded grafts had significantly fewer infections than control grafts did. The labeled penicillin G remained bound to both groups of antibiotic-bonded grafts for at least three weeks. In a second group of studies, surfactant-treated polytef adsorbed parenterally administered labeled penicillin G in highly significant concentrations compared with control grafts. These studies suggest the possibility that human vascular prosthetic infection may be treated with an antibiotic-bonded graft.

Original languageEnglish (US)
Pages (from-to)71-75
Number of pages5
JournalArchives of Surgery
Volume120
Issue number1
DOIs
StatePublished - Jan 1985

All Science Journal Classification (ASJC) codes

  • Surgery

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