The bed nucleus of the stria terminalis is critically involved in enhancing associative learning after stressful experience

Debra A. Bangasser, Jessica Santollo, Tracey J. Shors

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Exposure to an acute stressful event enhances trace eyeblink conditioning in male rats, even when rats begin training days after the stressor (Shors, 2001). The authors examined whether the bed nucleus of the stria terminalis (BNST), an area involved in stress and anxiety, is critically involved in this effect and, if so, when. The authors found that excitotoxic lesions to the BNST prevented the enhanced conditioning after stressor exposure. In addition, temporary inactivation of the BNST during the stressor did not alter enhanced responding, whereas inactivation during training prevented the enhancement. These data indicate that stressful experience induces persistent changes in the BNST that are necessary for enhancing learning well after the stressful event has ceased.

Original languageEnglish (US)
Pages (from-to)1459-1466
Number of pages8
JournalBehavioral Neuroscience
Volume119
Issue number6
DOIs
StatePublished - Dec 2005

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Keywords

  • Amygdala
  • Anxiety
  • Classical conditioning
  • Corticosterone
  • Eyeblink

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