The C. elegans spe-9 gene encodes a sperm transmembrane protein that contains EGF-like repeats and is required for fertilization

Andrew Singson, Kristina B. Mercer, Steven W. L'Hernault

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

In the nematode worm C. elegans, individuals with mutations in the spe- 9 gene produce spermatozoa with wild-type morphology and motility that cannot fertilize oocytes even after contact between gametes. Therefore, disruption of spe-9 function affects either gamete recognition, adhesion, signaling, and/or fusion. The spe-9 gene encodes a sperm transmembrane protein with an extracellular domain that contains ten epidermal growth factor-like repeats. A common feature of proteins that include epidermal growth factor-like motifs is their involvement in extracellular functions such as adhesive and ligand- receptor interactions. Additionally, the overall structure of the predicted SPE-9 protein is similar to that of ligands for the Notch/LIN-12/GLP-1 family of transmembrane receptors. These results suggest that SPE-9 functions in the specialized cell-cell interactions required for fertilization.

Original languageEnglish (US)
Pages (from-to)71-79
Number of pages9
JournalCell
Volume93
Issue number1
DOIs
StatePublished - Apr 3 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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