The Combined Effects of Exercise, Diet, and a Multi-Ingredient Dietary Supplement on Body Composition and Adipokine Changes in Overweight Adults

Shawn Arent, Alan J. Walker, Joseph K. Pellegrino, David J. Sanders, Bridget A. McFadden, Tim N. Ziegenfuss, Hector L. Lopez

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Very few weight and fat loss supplements undergo finished-product research to examine efficacy. The purpose of this study was to determine the effects of an 8-week diet and exercise program on body composition, hip and waist girth, and adipokines and evaluate whether a dietary supplement containing raspberry ketone, capsaicin, caffeine, garlic, and Citrus aurantium enhanced outcomes. Methods: Overweight men and women completed this randomized, placebo-controlled, double-blind study. Participants consumed 4 capsules/d of supplement (EXP; n = 18) or placebo (PLA; n = 18). Participants underwent 8 weeks of daily supplementation, calorie restriction (500 kcal < RMR [resting metabolic rate] × 1.2), and supervised progressive exercise training 3 times a week. Body composition, girth, and adipokines were assessed at baseline and postintervention (T1 and T2). Results: Significant decreases in weight (−2.6 ± 0.57 kg, p < 0.001), fat mass (−1.8 ± 0.20 kg; p < 0.001), and percentage body fat (−3.7% ± 0.29%, p < 0.001) and a significant increase in lean body mass (LBM; 1.5 ± 0.26 kg; p < 0.001) were seen from T1 to T2 in both groups. For men, only those in the EXP group increased LBM from T1 to T2 (1.3 ± 0.38 kg; p < 0.05). Hip girth was also reduced, with the women in the EXP group (−10.7 ± 2.15 cm, p < 0.001) having a greater reduction. There was a time by group interaction, with significant decreases in leptin (p < 0.001) and significant increases in adiponectin (p < 0.05) in the EXP group. Conclusions: Significant improvements in adipokines and leptin support the utility of exercise, diet, and fat loss for impacting inflammatory biomarkers. The improvement in adiponectin with EXP may suggest a unique health mechanism.

Original languageEnglish (US)
Pages (from-to)111-120
Number of pages10
JournalJournal of the American College of Nutrition
Volume37
Issue number2
DOIs
StatePublished - Feb 17 2018

Fingerprint

Adipokines
Dietary Supplements
Body Composition
Fats
Adiponectin
Exercise
Leptin
Diet
Hip
Placebos
Basal Metabolism
Garlic
Citrus
Capsaicin
Caffeine
Double-Blind Method
Capsules
Adipose Tissue
Weight Loss
Biomarkers

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Keywords

  • Dietary supplement
  • adipokine
  • body composition
  • capsaicin
  • fat loss
  • raspberry ketone

Cite this

Arent, Shawn ; Walker, Alan J. ; Pellegrino, Joseph K. ; Sanders, David J. ; McFadden, Bridget A. ; Ziegenfuss, Tim N. ; Lopez, Hector L. / The Combined Effects of Exercise, Diet, and a Multi-Ingredient Dietary Supplement on Body Composition and Adipokine Changes in Overweight Adults. In: Journal of the American College of Nutrition. 2018 ; Vol. 37, No. 2. pp. 111-120.
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The Combined Effects of Exercise, Diet, and a Multi-Ingredient Dietary Supplement on Body Composition and Adipokine Changes in Overweight Adults. / Arent, Shawn; Walker, Alan J.; Pellegrino, Joseph K.; Sanders, David J.; McFadden, Bridget A.; Ziegenfuss, Tim N.; Lopez, Hector L.

In: Journal of the American College of Nutrition, Vol. 37, No. 2, 17.02.2018, p. 111-120.

Research output: Contribution to journalArticle

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AU - Arent, Shawn

AU - Walker, Alan J.

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AU - Sanders, David J.

AU - McFadden, Bridget A.

AU - Ziegenfuss, Tim N.

AU - Lopez, Hector L.

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