The differentiation of glial cell progenitor populations following transplantation into non-repairing central nervous system glial lesions in adult animals

A. J. Crang, R. J.M. Franklin, W. F. Blakemore, M. Noble, S. C. Barnett, A. Groves, J. Trotter, M. Schachner

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

The non-repairing nature of the locally x-irradiated ethidium bromide (EB)-induced demyelinating white matter lesion has been further validated by showing that injections of two cultures which promote host remyelination of EB lesions in normal tissue do not do so in x-irradiated lesions. The behaviour of an oncogene-immortalized glial cell line and a growth-factor-expanded glial progenitor population have been examined following transplantation into the non-repairing EB lesion. Our studies indicate that the selected gell populations were eacable of establishing glial environments around demyelinated axons. Extensive oligodendrocyte remyelination with little astrocytic presence was observed in lesions transplanted with growth-factor-expanded optic nerve progenitors, while less extensive oligodendrocyte remyelination with the establishment of astrocyte-like cells was found in lesion transplanted with ts A58-SV40T immortalized glial cells. Prolonged expansion of both populations resulted in a loss of differentiation to normal glial phenotypes.

Original languageEnglish (US)
Pages (from-to)243-253
Number of pages11
JournalJournal of Neuroimmunology
Volume40
Issue number2-3
DOIs
StatePublished - Oct 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Keywords

  • Astrocyte
  • Axon
  • Growth factor
  • Oligodendrocyte
  • Oncogene
  • Remyelination

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