The distribution of intra-twin birth weight discordance and its association with total twin birth weight, gestational age, and neonatal mortality

Hongzhuan Tan, Wu Wen Shi, Karen Fung Kee Fung, Mark Walker, Kitaw Demissie

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Objective: To determine an appropriate cutoff value to differentiate physiologic and pathologic birth weight discordance, to determine the prevalence of birth weight discordance ≥25% among twin pregnancies in different sub-populations, and to examine its clinical significance. Study design: Historical cohort study of 147,262 twin sets registered in the United States between 1995 and 1997. Results: The prevalence of birth weight discordance ≥25% among twin pregnancies was 8.6%. The prevalence of birth weight discordance ≥25% was significantly decreased with increasing total twin birth weight deciles, was more frequently found in twins with discordant gender (9.1%) than in those twins with concordant gender (8.3%) and in mothers whose age was 30 years or older (9.1%) than those of younger mothers (8.1%). Birth weight discordance ≥25% was associated with earlier gestational age at delivery (35.0 weeks versus 36.0 weeks) and higher neonatal mortality (5.4% versus 2.3%) as compared to twins with lower birth weight discordance. Conclusions: The prevalence of birth weight discordance ≥25% among twin pregnancies was 8.6%, which is associated with lower gestational age at delivery and higher neonatal mortality rates, and may represent a pathologic process.

Original languageEnglish (US)
Pages (from-to)27-33
Number of pages7
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume121
Issue number1
DOIs
StatePublished - Jul 1 2005

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology

Keywords

  • Birth weight discordance
  • Gender concordance
  • Gestational age
  • Neonatal mortality

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