The dynamics of helicobacter pylori infection of the human stomach

Denise E. Kirschner, Martin J. Blaser

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Helicobacter pyloriis a bacterial pathogen of the gastrointestinal tract of humans causing chronic superficial gastritis which persists for decades. The mechanism by whichH. pyloriis able to persist, despite environmental constraints, remains unknown. Therefore, a model is proposed describing the interactions ofH. pyloriwith its host, involving an autoregulatory network in which inflammation leads to nutrient release. A determinist mathematical model examining the interactions necessary to maintain chronic infection indicates that this proposed autoregulatory network can produce steady-state solutions, and the model is robust in encompassing biological variations.

Original languageEnglish (US)
Pages (from-to)281-290
Number of pages10
JournalJournal of Theoretical Biology
Volume176
Issue number2
DOIs
StatePublished - Sep 21 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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