The dynamics of helicobacter pylori infection of the human stomach

Denise E. Kirschner; Martin J. Blaser

doi:10.1006/jtbi.1995.0198

The dynamics of helicobacter pylori infection of the human stomach

Denise E. Kirschner, Martin J. Blaser

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

Helicobacter pyloriis a bacterial pathogen of the gastrointestinal tract of humans causing chronic superficial gastritis which persists for decades. The mechanism by whichH. pyloriis able to persist, despite environmental constraints, remains unknown. Therefore, a model is proposed describing the interactions ofH. pyloriwith its host, involving an autoregulatory network in which inflammation leads to nutrient release. A determinist mathematical model examining the interactions necessary to maintain chronic infection indicates that this proposed autoregulatory network can produce steady-state solutions, and the model is robust in encompassing biological variations.

Original language	English (US)
Pages (from-to)	281-290
Number of pages	10
Journal	Journal of Theoretical Biology
Volume	176
Issue number	2
DOIs	https://doi.org/10.1006/jtbi.1995.0198
State	Published - Sep 21 1995
Externally published	Yes

All Science Journal Classification (ASJC) codes

Statistics and Probability
Modeling and Simulation
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Agricultural and Biological Sciences(all)
Applied Mathematics

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10.1006/jtbi.1995.0198

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title = "The dynamics of helicobacter pylori infection of the human stomach",

abstract = "Helicobacter pyloriis a bacterial pathogen of the gastrointestinal tract of humans causing chronic superficial gastritis which persists for decades. The mechanism by whichH. pyloriis able to persist, despite environmental constraints, remains unknown. Therefore, a model is proposed describing the interactions ofH. pyloriwith its host, involving an autoregulatory network in which inflammation leads to nutrient release. A determinist mathematical model examining the interactions necessary to maintain chronic infection indicates that this proposed autoregulatory network can produce steady-state solutions, and the model is robust in encompassing biological variations.",

author = "Kirschner, {Denise E.} and Blaser, {Martin J.}",

note = "Funding Information: We thank Douglas Berg\ Alan Perelson\ Philip Russell\ Glenn Webb and Mary Ballyk for helpful discussions and comments[ Part of this work was supported by grant R90CA47723 from the National Cancer Institute\ and by the Medical Research Service of the Department of Veterans A}airs[",

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AU - Kirschner, Denise E.

AU - Blaser, Martin J.

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N2 - Helicobacter pyloriis a bacterial pathogen of the gastrointestinal tract of humans causing chronic superficial gastritis which persists for decades. The mechanism by whichH. pyloriis able to persist, despite environmental constraints, remains unknown. Therefore, a model is proposed describing the interactions ofH. pyloriwith its host, involving an autoregulatory network in which inflammation leads to nutrient release. A determinist mathematical model examining the interactions necessary to maintain chronic infection indicates that this proposed autoregulatory network can produce steady-state solutions, and the model is robust in encompassing biological variations.

AB - Helicobacter pyloriis a bacterial pathogen of the gastrointestinal tract of humans causing chronic superficial gastritis which persists for decades. The mechanism by whichH. pyloriis able to persist, despite environmental constraints, remains unknown. Therefore, a model is proposed describing the interactions ofH. pyloriwith its host, involving an autoregulatory network in which inflammation leads to nutrient release. A determinist mathematical model examining the interactions necessary to maintain chronic infection indicates that this proposed autoregulatory network can produce steady-state solutions, and the model is robust in encompassing biological variations.

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The dynamics of helicobacter pylori infection of the human stomach

Abstract

All Science Journal Classification (ASJC) codes

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