The dynamics of the early inflammatory response in double-hit burn and sepsis animal models

Mehmet A. Orman, Marianthi G. Ierapetritou, Francois Berthiaume, Ioannis P. Androulakis

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Severe burn trauma is generally associated with bacterial infections, which causes a more persistent inflammatory response with an ongoing hypermetabolic and catabolic state. This complex biological response, mediated by chemokines and cytokines, can be more severe when excessive interactions between the mediators take place. In this study, the early inflammatory response following the cecum ligation and puncture (CLP) or its corresponding control treatment (sham-CLP or SCLP) in burn (B) male rats was analyzed by measuring 23 different cytokines and chemokines. Cytokines and chemokines, including MCP-1, IP-10, leptin, TNF-α, MIP-1α, IL-18, GMCSF, RANTES and GCSF were significantly altered in both B+CLP and B+SCLP groups. IL-10 and IL-6 were significantly up-regulated in the B+CLP group when compared to the B+SCLP group. Down regulation of leptin and IP-10 concentrations were found to be related to surgery and/or infection. IL-18 and MCP-1 were elevated in all groups including previously published single injury models receiving similar treatments. In this study, insult-specific mediators with their characteristic temporal patterns were elucidated in double hit models.

Original languageEnglish (US)
Pages (from-to)494-502
Number of pages9
Issue number2
StatePublished - Nov 2011

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology


  • Burn injury
  • Cecum ligation and puncture
  • Chemokines
  • Cytokines
  • Double-hit injury models


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