The dysregulation of the endocannabinoid system in diabesity-a tricky problem

Thomas Scherer, Christoph Buettner

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Endocannabinoids (ECs) are small lipid mediators that play a critical role in energy metabolism. Human studies have shown that the EC tone in peripheral tissues positively correlates with increased adiposity. Furthermore, pharmacological inhibition of EC signaling results in weight loss in humans. However, the mechanisms that cause the dysregulation of the EC system in obesity are not well-understood. Since the clinical utility of currently available EC blockers is severely limited due to their side effects like depression and suicidal ideation that are caused by central effects, it is important to delineate the role of central and peripheral effects of EC signaling in regulating glucose and lipid metabolism.

Original languageEnglish (US)
Pages (from-to)663-668
Number of pages6
JournalJournal of Molecular Medicine
Volume87
Issue number7
DOIs
StatePublished - Jul 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Genetics(clinical)

Keywords

  • Adipose tissue
  • Endocannabinoids
  • Fat metabolism
  • Leptin action
  • Mediobasal hypothalamus

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