The Effect of Cold Gamma Radiation Sterilisation on the Properties of Demineralised Bone Matrix

Arthur A. Gertzman, Moon Hae Sunwoo, Denise Raushi, Michael Dunn

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Demineralised bone in a viscous hyaluronan carrier was processed at sterilising and sub-sterilising doses of gamma radiation (10.2, 17.2 and 29.5 kGy). The pH, viscosity and osteoinductivity were measured. Osteoinductivity (OI) measured by implantation in an athymic (nude) mouse demonstrated significant loss at a dose of 17.2 kGy; OI scores declined 53% (p = 0.024). Viscosity also declined with increasing radiation dose. pH was unaffected.

Original languageEnglish (US)
Title of host publicationSterilisation of Tissues Using Ionising Radiations
PublisherElsevier Inc.
Pages151-156
Number of pages6
ISBN (Print)1855738384, 9781855738386
DOIs
StatePublished - May 6 2005

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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