The Effect of Cold Gamma Radiation Sterilisation on the Properties of Demineralised Bone Matrix

Arthur A. Gertzman; Moon Hae Sunwoo; Denise Raushi; Michael Dunn

doi:10.1533/9781845690779.3.151

The Effect of Cold Gamma Radiation Sterilisation on the Properties of Demineralised Bone Matrix

Arthur A. Gertzman, Moon Hae Sunwoo, Denise Raushi, Michael Dunn

Robert Wood Johnson Medical School (RWJMS), Orthopedic Surgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

Demineralised bone in a viscous hyaluronan carrier was processed at sterilising and sub-sterilising doses of gamma radiation (10.2, 17.2 and 29.5 kGy). The pH, viscosity and osteoinductivity were measured. Osteoinductivity (OI) measured by implantation in an athymic (nude) mouse demonstrated significant loss at a dose of 17.2 kGy; OI scores declined 53% (p = 0.024). Viscosity also declined with increasing radiation dose. pH was unaffected.

Original language	English (US)
Title of host publication	Sterilisation of Tissues Using Ionising Radiations
Publisher	Elsevier Inc.
Pages	151-156
Number of pages	6
ISBN (Print)	1855738384, 9781855738386
DOIs	https://doi.org/10.1533/9781845690779.3.151
State	Published - May 6 2005

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1533/9781845690779.3.151

Cite this

@inbook{97f48989d5a842288453ac82f8414c6c,

title = "The Effect of Cold Gamma Radiation Sterilisation on the Properties of Demineralised Bone Matrix",

abstract = "Demineralised bone in a viscous hyaluronan carrier was processed at sterilising and sub-sterilising doses of gamma radiation (10.2, 17.2 and 29.5 kGy). The pH, viscosity and osteoinductivity were measured. Osteoinductivity (OI) measured by implantation in an athymic (nude) mouse demonstrated significant loss at a dose of 17.2 kGy; OI scores declined 53% (p = 0.024). Viscosity also declined with increasing radiation dose. pH was unaffected.",

author = "Gertzman, {Arthur A.} and Sunwoo, {Moon Hae} and Denise Raushi and Michael Dunn",

year = "2005",

month = may,

day = "6",

doi = "10.1533/9781845690779.3.151",

language = "English (US)",

isbn = "1855738384",

pages = "151--156",

booktitle = "Sterilisation of Tissues Using Ionising Radiations",

publisher = "Elsevier Inc.",

address = "United States",

}

TY - CHAP

T1 - The Effect of Cold Gamma Radiation Sterilisation on the Properties of Demineralised Bone Matrix

AU - Gertzman, Arthur A.

AU - Sunwoo, Moon Hae

AU - Raushi, Denise

AU - Dunn, Michael

PY - 2005/5/6

Y1 - 2005/5/6

N2 - Demineralised bone in a viscous hyaluronan carrier was processed at sterilising and sub-sterilising doses of gamma radiation (10.2, 17.2 and 29.5 kGy). The pH, viscosity and osteoinductivity were measured. Osteoinductivity (OI) measured by implantation in an athymic (nude) mouse demonstrated significant loss at a dose of 17.2 kGy; OI scores declined 53% (p = 0.024). Viscosity also declined with increasing radiation dose. pH was unaffected.

AB - Demineralised bone in a viscous hyaluronan carrier was processed at sterilising and sub-sterilising doses of gamma radiation (10.2, 17.2 and 29.5 kGy). The pH, viscosity and osteoinductivity were measured. Osteoinductivity (OI) measured by implantation in an athymic (nude) mouse demonstrated significant loss at a dose of 17.2 kGy; OI scores declined 53% (p = 0.024). Viscosity also declined with increasing radiation dose. pH was unaffected.

UR - http://www.scopus.com/inward/record.url?scp=33846333279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846333279&partnerID=8YFLogxK

U2 - 10.1533/9781845690779.3.151

DO - 10.1533/9781845690779.3.151

M3 - Chapter

AN - SCOPUS:33846333279

SN - 1855738384

SN - 9781855738386

SP - 151

EP - 156

BT - Sterilisation of Tissues Using Ionising Radiations

PB - Elsevier Inc.

ER -

The Effect of Cold Gamma Radiation Sterilisation on the Properties of Demineralised Bone Matrix

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this