The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin

Fritz Francois, Jatin Roper, Neal Joseph, Zhiheng Pei, Aditi Chhada, Joshua R. Shak, Asalia Z.O. de Perez, Guillermo I. Perez-Perez, Martin Blaser

Research output: Contribution to journalArticle

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Abstract

Background: Appetite and energy expenditure are regulated in part by ghrelin and leptin produced in the gastric mucosa, which may be modified by H. pylori colonization. We prospectively evaluated the effect of H. pylori eradication on meal-associated changes in serum ghrelin and leptin levels, and body weight.Methods: Veterans referred for upper GI endoscopy were evaluated at baseline and ≥8 weeks after endoscopy, and H. pylori status and body weight were ascertained. During the first visit in all subjects, and during subsequent visits in the initially H. pylori-positive subjects and controls, blood was collected after an overnight fast and 1 h after a standard high protein meal, and levels of eight hormones determined.Results: Of 92 enrolled subjects, 38 were H. pylori-negative, 44 H. pylori-positive, and 10 were indeterminate. Among 23 H. pylori-positive subjects who completed evaluation after treatment, 21 were eradicated, and 2 failed eradication. After a median of seven months following eradication, six hormones related to energy homeostasis showed no significant differences, but post-prandial acylated ghrelin levels were nearly six-fold higher than pre-eradication (p = 0.005), and median integrated leptin levels also increased (20%) significantly (p < 0.001). BMI significantly increased (5 ± 2%; p = 0.008) over 18 months in the initially H. pylori-positive individuals, but was not significantly changed in those who were H. pylori-negative or indeterminant at baseline.Conclusions: Circulating meal-associated leptin and ghrelin levels and BMI changed significantly after H. pylori eradication, providing direct evidence that H. pylori colonization is involved in ghrelin and leptin regulation, with consequent effects on body morphometry.

Original languageEnglish (US)
Article number37
JournalBMC Gastroenterology
Volume11
DOIs
StatePublished - Apr 14 2011

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Ghrelin
Pylorus
Leptin
Meals
Endoscopy
Body Weight
Hormones
Veterans
Appetite
Gastric Mucosa
Energy Metabolism
Homeostasis

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Francois, Fritz ; Roper, Jatin ; Joseph, Neal ; Pei, Zhiheng ; Chhada, Aditi ; Shak, Joshua R. ; de Perez, Asalia Z.O. ; Perez-Perez, Guillermo I. ; Blaser, Martin. / The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin. In: BMC Gastroenterology. 2011 ; Vol. 11.
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abstract = "Background: Appetite and energy expenditure are regulated in part by ghrelin and leptin produced in the gastric mucosa, which may be modified by H. pylori colonization. We prospectively evaluated the effect of H. pylori eradication on meal-associated changes in serum ghrelin and leptin levels, and body weight.Methods: Veterans referred for upper GI endoscopy were evaluated at baseline and ≥8 weeks after endoscopy, and H. pylori status and body weight were ascertained. During the first visit in all subjects, and during subsequent visits in the initially H. pylori-positive subjects and controls, blood was collected after an overnight fast and 1 h after a standard high protein meal, and levels of eight hormones determined.Results: Of 92 enrolled subjects, 38 were H. pylori-negative, 44 H. pylori-positive, and 10 were indeterminate. Among 23 H. pylori-positive subjects who completed evaluation after treatment, 21 were eradicated, and 2 failed eradication. After a median of seven months following eradication, six hormones related to energy homeostasis showed no significant differences, but post-prandial acylated ghrelin levels were nearly six-fold higher than pre-eradication (p = 0.005), and median integrated leptin levels also increased (20{\%}) significantly (p < 0.001). BMI significantly increased (5 ± 2{\%}; p = 0.008) over 18 months in the initially H. pylori-positive individuals, but was not significantly changed in those who were H. pylori-negative or indeterminant at baseline.Conclusions: Circulating meal-associated leptin and ghrelin levels and BMI changed significantly after H. pylori eradication, providing direct evidence that H. pylori colonization is involved in ghrelin and leptin regulation, with consequent effects on body morphometry.",
author = "Fritz Francois and Jatin Roper and Neal Joseph and Zhiheng Pei and Aditi Chhada and Shak, {Joshua R.} and {de Perez}, {Asalia Z.O.} and Perez-Perez, {Guillermo I.} and Martin Blaser",
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Francois, F, Roper, J, Joseph, N, Pei, Z, Chhada, A, Shak, JR, de Perez, AZO, Perez-Perez, GI & Blaser, M 2011, 'The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin', BMC Gastroenterology, vol. 11, 37. https://doi.org/10.1186/1471-230X-11-37

The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin. / Francois, Fritz; Roper, Jatin; Joseph, Neal; Pei, Zhiheng; Chhada, Aditi; Shak, Joshua R.; de Perez, Asalia Z.O.; Perez-Perez, Guillermo I.; Blaser, Martin.

In: BMC Gastroenterology, Vol. 11, 37, 14.04.2011.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin

AU - Francois, Fritz

AU - Roper, Jatin

AU - Joseph, Neal

AU - Pei, Zhiheng

AU - Chhada, Aditi

AU - Shak, Joshua R.

AU - de Perez, Asalia Z.O.

AU - Perez-Perez, Guillermo I.

AU - Blaser, Martin

PY - 2011/4/14

Y1 - 2011/4/14

N2 - Background: Appetite and energy expenditure are regulated in part by ghrelin and leptin produced in the gastric mucosa, which may be modified by H. pylori colonization. We prospectively evaluated the effect of H. pylori eradication on meal-associated changes in serum ghrelin and leptin levels, and body weight.Methods: Veterans referred for upper GI endoscopy were evaluated at baseline and ≥8 weeks after endoscopy, and H. pylori status and body weight were ascertained. During the first visit in all subjects, and during subsequent visits in the initially H. pylori-positive subjects and controls, blood was collected after an overnight fast and 1 h after a standard high protein meal, and levels of eight hormones determined.Results: Of 92 enrolled subjects, 38 were H. pylori-negative, 44 H. pylori-positive, and 10 were indeterminate. Among 23 H. pylori-positive subjects who completed evaluation after treatment, 21 were eradicated, and 2 failed eradication. After a median of seven months following eradication, six hormones related to energy homeostasis showed no significant differences, but post-prandial acylated ghrelin levels were nearly six-fold higher than pre-eradication (p = 0.005), and median integrated leptin levels also increased (20%) significantly (p < 0.001). BMI significantly increased (5 ± 2%; p = 0.008) over 18 months in the initially H. pylori-positive individuals, but was not significantly changed in those who were H. pylori-negative or indeterminant at baseline.Conclusions: Circulating meal-associated leptin and ghrelin levels and BMI changed significantly after H. pylori eradication, providing direct evidence that H. pylori colonization is involved in ghrelin and leptin regulation, with consequent effects on body morphometry.

AB - Background: Appetite and energy expenditure are regulated in part by ghrelin and leptin produced in the gastric mucosa, which may be modified by H. pylori colonization. We prospectively evaluated the effect of H. pylori eradication on meal-associated changes in serum ghrelin and leptin levels, and body weight.Methods: Veterans referred for upper GI endoscopy were evaluated at baseline and ≥8 weeks after endoscopy, and H. pylori status and body weight were ascertained. During the first visit in all subjects, and during subsequent visits in the initially H. pylori-positive subjects and controls, blood was collected after an overnight fast and 1 h after a standard high protein meal, and levels of eight hormones determined.Results: Of 92 enrolled subjects, 38 were H. pylori-negative, 44 H. pylori-positive, and 10 were indeterminate. Among 23 H. pylori-positive subjects who completed evaluation after treatment, 21 were eradicated, and 2 failed eradication. After a median of seven months following eradication, six hormones related to energy homeostasis showed no significant differences, but post-prandial acylated ghrelin levels were nearly six-fold higher than pre-eradication (p = 0.005), and median integrated leptin levels also increased (20%) significantly (p < 0.001). BMI significantly increased (5 ± 2%; p = 0.008) over 18 months in the initially H. pylori-positive individuals, but was not significantly changed in those who were H. pylori-negative or indeterminant at baseline.Conclusions: Circulating meal-associated leptin and ghrelin levels and BMI changed significantly after H. pylori eradication, providing direct evidence that H. pylori colonization is involved in ghrelin and leptin regulation, with consequent effects on body morphometry.

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