The Effect of Immunobiotic/Psychobiotic Lactobacillus acidophilus Strain INMIA 9602 Er 317/402 Narine on Gut Prevotella in Familial Mediterranean Fever: Gender-Associated Effects

Astghik Z. Pepoyan, Elya S. Pepoyan, Lilit Galstyan, Natalya A. Harutyunyan, Vardan V. Tsaturyan, Tamas Torok, Alexey M. Ermakov, Igor V. Popov, Richard Weeks, Michael L. Chikindas

Research output: Contribution to journalArticlepeer-review

Abstract

Possible mechanisms involved in sex-dependent differences in the gut microbiota have a growing interest worldwide, but the effects of probiotics dependence on the gender of the host have remained outside of researchers’ attention until now. Previously, our research data described gender-specific differences in the gut microbiota of Armenian Familial Mediterranean fever (FMF) patients. Taking into account the possible association of Prevotella spp. with depressive disorders, the aim of the current investigations was an evaluation of changes in the abundance of gut Prevotella of FMF patients in association with the patient’s depression and gender. The differences between healthy and FMF diseased gut microbiota in terms of Prevotella abundance were revealed. In addition, the gender-dependent effects of immunobiotic/psychobiotic Narine on the abundance of gut Prevotella of FMF patients and patients’ depression scores were shown by us in this study.

Original languageEnglish (US)
Pages (from-to)1306-1315
Number of pages10
JournalProbiotics and Antimicrobial Proteins
Volume13
Issue number5
DOIs
StatePublished - Oct 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Medicine
  • Molecular Biology

Keywords

  • Depression level
  • Familial Mediterranean fever
  • Gut microbiota
  • Immunobiotic Narine
  • Patients’ gender
  • Prevotella
  • Psychobiotic

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