The effect of intermittent vs. continuous training on walking endurance and fatigue in people with multiple sclerosis: A randomized, crossover trial

Herb I. Karpatkin, Evan T. Cohen, Stefanie DiCarrado, Bridget Dungan, Jake Potrzeba, Elizabeth Huallpa, J. Scott Parrott

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To compare effects of an intermittent and continuous walking program on walking endurance and fatigue in people with multiple sclerosis (MS) Design: A randomized crossover prospective study Setting: An outpatient rehabilitation clinic Patients: A convenience sample of 12 participants with MS (median Expanded Disability Status Scale = 3.0, interquartile range [IQR] 3.25); 9 participants completed the study. Interventions: The intervention consisted of eight 6-minute-long walks (2x/week for 4 weeks). The continuous condition consisted of 6 continuous minutes of walking. The intermittent condition consisted of three 2-minute bouts with 2-minute rests. After a 4-week detraining period, participants performed the second training condition. Main Outcome Measurements: Outcomes included fatigue severity scale (FSS), the 6-minute walk test (6MWT), and the difference in a 100-mm visual analog scale of fatigue (δVAS-F) measured immediately before and after the 6MWT. Results: The 6MWT distance increased after intermittent training (43.6 m, p = .013) and decreased after continuous training (-18.0 m, p = .362). The FSS decreased after intermittent training (p = .032) but not after continuous training. No differences were found in δVAS-F. Conclusion: Intermittent training was superior to continuous training in improving walking and fatigue. Intermittent walking training should be considered to improve walking endurance and decrease fatigue in people with MS.

Original languageEnglish (US)
Pages (from-to)33-45
Number of pages13
JournalCritical Reviews in Physical and Rehabilitation Medicine
Volume28
Issue number1-2
DOIs
StatePublished - 2016

All Science Journal Classification (ASJC) codes

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation

Keywords

  • Fatigue
  • Gait
  • Multiple sclerosis
  • Rehabilitation
  • Walking

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