The effect of mannoheptulose on the phosphorylation of glucose and the secretion of insulin by islets of Langerhans

Willy J. Malaisse, Michael A. Lea, Francine Malaisse-Lagae

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88 Scopus citations

Abstract

Insulin secretion induced in vitro by glucose in pancreatic tissue of the rat is unaffected by addition of phloridzin and 3-0-methylglucose to the incubation media, suggesting that the beta-cells are freely permeable to glucose. D-glucosamine and mannoheptulose markedly inhibit the stimulant effect of glucose upon insulin secretion. The inhibitory effect of mannoheptulose is reversible and of the competitive type. Mannoheptulose also competitively inhibits the phosphorylation of glucose by isolated islet homogenates. Phosphorylation of glucose thus appears as a necessary step in the stimulation of insulin secretion by this sugar.

Original languageEnglish (US)
Pages (from-to)126-132
Number of pages7
JournalMetabolism
Volume17
Issue number2
DOIs
StatePublished - Feb 1968
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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