The effects of inotropic stimulation on ischemic myocardium in conscious dogs

S. F. Vatner, H. Baig

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Inotropic stimulation can be deleterious to the ischemic heart, since increasing myocardial metabolic demands in a situation of limited oxygen supply can exaggerate the imbalance between these two critical determinants of myocardial function. In order to determine if this action on ischemic myocardium is peculiar to isoproterenol or endemic to inotropic stimulation per se, the effects of isoproterenol were compared with equi-inotropic doses of other adrenergic agents that do not induce substantial changes in heart rate and arterial pressure, e.g. dopamine and dobutamine, and also with a non-adrenergic inotropic agent, ouabain. The effects of these drugs were examined in the presence of acute myocardial ischemia in conscious animals, since anesthesia and recent surgery alter the normal control of the circulation.

Original languageEnglish (US)
Pages (from-to)282-293
Number of pages12
JournalTransactions of the Association of American Physicians
VolumeVol. 91
StatePublished - 1978
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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