Abstract
An animal model of haloperidol-induced tardive dyskinesia was studied in relation to the dietary manipulation of tryptophan and its effect on the movement disorder. This study showed a significant negative behavioral response to the neuroleptic drug, haloperidol. Increased dietary tryptophan (1.0 vs. 0.3%) significantly reduced the frequency of drug-induced head movements. Brain serotonin levels were elevated by the drug treatment. Brain serotonin levels correlated significantly with the behavioral response. Contrary to expectation, brain dopamine levels did not correlate with the behavioral response. These findings suggest a possible serotonergic involvement in neuroleptic-induced tardive dyskinesia and an amelioration of the disorder through tryptophan supplementation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1739-1744 |
| Number of pages | 6 |
| Journal | Life Sciences |
| Volume | 41 |
| Issue number | 14 |
| DOIs | |
| State | Published - Oct 5 1987 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
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The effects of L-tryptophan on haloperidol-induced movement disorder in the rat. / Kozell, Laura; Sandyk, Reuven; Wagner, George; Fisher, Hans.
In: Life Sciences, Vol. 41, No. 14, 05.10.1987, p. 1739-1744.Research output: Contribution to journal › Article
TY - JOUR
T1 - The effects of L-tryptophan on haloperidol-induced movement disorder in the rat
AU - Kozell, Laura
AU - Sandyk, Reuven
AU - Wagner, George
AU - Fisher, Hans
PY - 1987/10/5
Y1 - 1987/10/5
N2 - An animal model of haloperidol-induced tardive dyskinesia was studied in relation to the dietary manipulation of tryptophan and its effect on the movement disorder. This study showed a significant negative behavioral response to the neuroleptic drug, haloperidol. Increased dietary tryptophan (1.0 vs. 0.3%) significantly reduced the frequency of drug-induced head movements. Brain serotonin levels were elevated by the drug treatment. Brain serotonin levels correlated significantly with the behavioral response. Contrary to expectation, brain dopamine levels did not correlate with the behavioral response. These findings suggest a possible serotonergic involvement in neuroleptic-induced tardive dyskinesia and an amelioration of the disorder through tryptophan supplementation.
AB - An animal model of haloperidol-induced tardive dyskinesia was studied in relation to the dietary manipulation of tryptophan and its effect on the movement disorder. This study showed a significant negative behavioral response to the neuroleptic drug, haloperidol. Increased dietary tryptophan (1.0 vs. 0.3%) significantly reduced the frequency of drug-induced head movements. Brain serotonin levels were elevated by the drug treatment. Brain serotonin levels correlated significantly with the behavioral response. Contrary to expectation, brain dopamine levels did not correlate with the behavioral response. These findings suggest a possible serotonergic involvement in neuroleptic-induced tardive dyskinesia and an amelioration of the disorder through tryptophan supplementation.
UR - http://www.scopus.com/inward/record.url?scp=0023583719&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023583719&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(87)90602-3
DO - 10.1016/0024-3205(87)90602-3
M3 - Article
C2 - 3657380
AN - SCOPUS:0023583719
VL - 41
SP - 1739
EP - 1744
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 14
ER -