@article{cbce676222fa41dfa4a609d90fe139e0,
title = "The effects of L-tryptophan on haloperidol-induced movement disorder in the rat",
abstract = "An animal model of haloperidol-induced tardive dyskinesia was studied in relation to the dietary manipulation of tryptophan and its effect on the movement disorder. This study showed a significant negative behavioral response to the neuroleptic drug, haloperidol. Increased dietary tryptophan (1.0 vs. 0.3%) significantly reduced the frequency of drug-induced head movements. Brain serotonin levels were elevated by the drug treatment. Brain serotonin levels correlated significantly with the behavioral response. Contrary to expectation, brain dopamine levels did not correlate with the behavioral response. These findings suggest a possible serotonergic involvement in neuroleptic-induced tardive dyskinesia and an amelioration of the disorder through tryptophan supplementation.",
author = "Laura Kozell and Reuven Sandyk and Wagner, {George C.} and Hans Fisher",
note = "Funding Information: Tardive dyskinesia (TD) refers to an abnormal movement disorder involving the buccal-lingual and masticatory muscular region (Lr6)!.~ The disorder usually arises after prolonged use of antipsychotic~drugs. All classes of antipsychotics share the ability to antagonize dopamine by competitive blockade at receptor sites (I0), and this proPe=tM,is believed to be fundamental to the pathogenesis of TD. In experimental animals, prolonged treatment with dopamine-blocking drugs map lead to enhanced sensitivity to the behavioral and pharmacological effects of dopamine agonists and to increased binding of dopamine receptor ligands (II). Dopamine antagonist-induced receptor supersensitivity may be relevant to the pathophysiology of some movement disorders, but its relevance to TD is unknown (12). Recently one of us (7) reported that a dietary L-tryptophan supplement, given as treatment for insomnia to a patient with neuroleptic-induced TD, reduced the severity of the INew Jersey Agricultural Experiment Station publication No. D-14101-3-87. Supported by State funds and by a grant from the Charles and Johanna Busch 5Fund. To whom reprint requests should be addressed.",
year = "1987",
month = oct,
day = "5",
doi = "10.1016/0024-3205(87)90602-3",
language = "English (US)",
volume = "41",
pages = "1739--1744",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "14",
}