The electropharmacological effects of high dose resibufogenin on guinea pig cardiac muscle

J. Y. Li, Lai-Hua Xie

Research output: Contribution to journalArticle

Abstract

Electropharmacological effects of resibufogenin (RBG) on guinea pig papillary muscle were studied by means of conventional glass microelectrode technique. The results were as follows: After being treated with RBG, the resting potential (RP), action potential amplitude (APA), action potential duration (APD) and V(max) decreased, delayed afterdepolarization (DAD) and triggered arrhythmias were induced. The amplitude and coupling interval of DADs depended on the basic cycle length (BCL) of the stimulation. The effects of RBG on the membrane potential of papillary muscle were concentration-dependent.

Original languageEnglish (US)
Pages (from-to)110-113
Number of pages4
JournalChinese Pharmacological Bulletin
Volume10
Issue number2
StatePublished - Jan 1 1994
Externally publishedYes

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Myocardium
Guinea Pigs
Papillary Muscles
Membrane Potentials
Action Potentials
Microelectrodes
Glass
Cardiac Arrhythmias
bufogenin

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

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The electropharmacological effects of high dose resibufogenin on guinea pig cardiac muscle. / Li, J. Y.; Xie, Lai-Hua.

In: Chinese Pharmacological Bulletin, Vol. 10, No. 2, 01.01.1994, p. 110-113.

Research output: Contribution to journalArticle

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