Electropharmacological effects of resibufogenin (RBG) on guinea pig papillary muscle were studied by means of conventional glass microelectrode technique. The results were as follows: After being treated with RBG, the resting potential (RP), action potential amplitude (APA), action potential duration (APD) and V(max) decreased, delayed afterdepolarization (DAD) and triggered arrhythmias were induced. The amplitude and coupling interval of DADs depended on the basic cycle length (BCL) of the stimulation. The effects of RBG on the membrane potential of papillary muscle were concentration-dependent.
|Original language||English (US)|
|Number of pages||4|
|Journal||Chinese Pharmacological Bulletin|
|Publication status||Published - Jan 1 1994|
All Science Journal Classification (ASJC) codes