The enteric toxicity of gluten enhances graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Taylor Neuman, Kevin David, Dennis Cooper, Roger Strair

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Pro-inflammatory peptides present in wheat and related grains are associated with celiac disease and non-celiac gluten sensitivity. We hypothesize that these peptides induce enteric responses that may exacerbate the gastrointestinal manifestations of graft-versus-host disease after an allogeneic hematopoietic stem cell transplant. Therefore, we propose that a gluten free diet should be tested as a prophylactic and/or therapeutic intervention against gastrointestinal graft-versus-host disease for patients undergoing an allogeneic hematopoietic stem cell transplant.

Original languageEnglish (US)
Pages (from-to)174-177
Number of pages4
JournalMedical Hypotheses
Volume104
DOIs
StatePublished - Jul 2017

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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