The enteric toxicity of gluten enhances graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Taylor Neuman; Kevin David; Dennis Cooper; Roger Strair

doi:10.1016/j.mehy.2017.05.037

The enteric toxicity of gluten enhances graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Taylor Neuman, Kevin David, Dennis Cooper, Roger Strair

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Abstract

Pro-inflammatory peptides present in wheat and related grains are associated with celiac disease and non-celiac gluten sensitivity. We hypothesize that these peptides induce enteric responses that may exacerbate the gastrointestinal manifestations of graft-versus-host disease after an allogeneic hematopoietic stem cell transplant. Therefore, we propose that a gluten free diet should be tested as a prophylactic and/or therapeutic intervention against gastrointestinal graft-versus-host disease for patients undergoing an allogeneic hematopoietic stem cell transplant.

Original language	English (US)
Pages (from-to)	174-177
Number of pages	4
Journal	Medical Hypotheses
Volume	104
DOIs	https://doi.org/10.1016/j.mehy.2017.05.037
State	Published - Jul 2017

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1016/j.mehy.2017.05.037

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title = "The enteric toxicity of gluten enhances graft-versus-host disease after allogeneic hematopoietic stem cell transplantation",

abstract = "Pro-inflammatory peptides present in wheat and related grains are associated with celiac disease and non-celiac gluten sensitivity. We hypothesize that these peptides induce enteric responses that may exacerbate the gastrointestinal manifestations of graft-versus-host disease after an allogeneic hematopoietic stem cell transplant. Therefore, we propose that a gluten free diet should be tested as a prophylactic and/or therapeutic intervention against gastrointestinal graft-versus-host disease for patients undergoing an allogeneic hematopoietic stem cell transplant.",

author = "Taylor Neuman and Kevin David and Dennis Cooper and Roger Strair",

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AU - Neuman, Taylor

AU - David, Kevin

AU - Cooper, Dennis

AU - Strair, Roger

PY - 2017/7

Y1 - 2017/7

N2 - Pro-inflammatory peptides present in wheat and related grains are associated with celiac disease and non-celiac gluten sensitivity. We hypothesize that these peptides induce enteric responses that may exacerbate the gastrointestinal manifestations of graft-versus-host disease after an allogeneic hematopoietic stem cell transplant. Therefore, we propose that a gluten free diet should be tested as a prophylactic and/or therapeutic intervention against gastrointestinal graft-versus-host disease for patients undergoing an allogeneic hematopoietic stem cell transplant.

AB - Pro-inflammatory peptides present in wheat and related grains are associated with celiac disease and non-celiac gluten sensitivity. We hypothesize that these peptides induce enteric responses that may exacerbate the gastrointestinal manifestations of graft-versus-host disease after an allogeneic hematopoietic stem cell transplant. Therefore, we propose that a gluten free diet should be tested as a prophylactic and/or therapeutic intervention against gastrointestinal graft-versus-host disease for patients undergoing an allogeneic hematopoietic stem cell transplant.

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JO - Medical Hypotheses

JF - Medical Hypotheses

SN - 0306-9877

ER -

The enteric toxicity of gluten enhances graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Abstract

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