The Escherichia coli ras-like protein (Era) has GTPase activity and is essential for cell growth

P. E. March, C. G. Lerner, J. Ahnn, X. Cui, M. Inouye

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

The era gene of Escherichia coli encodes a protein (Era) which is similar to the eucaryotic RAS family of proteins. We report here that purified Era possesses both GTP-binding and GTPase activities. Era is also shown to be loosely associated with the inner membrane of E. coli. Overproduction of Era to 5% of the total cellular protein does not apparently alter either cell growth or cAMP levels. Disruption of the era gene by insertional inactivation is shown to be lethal by construction of a condition lethal era mutant strain.

Original languageEnglish (US)
Pages (from-to)539-544
Number of pages6
JournalOncogene
Volume2
Issue number6
StatePublished - 1988

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

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