The Escherichia coli RNA polymerase α subunit: structure and function

Richard H. Ebright, Steve Busby

Research output: Contribution to journalArticlepeer-review

129 Scopus citations

Abstract

Recent work has established that the Escherichia coli RNA polymerase α subunit consists of an amino-terminal domain containing determinants for interaction with the remainder of RNA polymerase, a carboxy-terminal domain containing determinants for interaction with DNA and interaction with transcriptional activator proteins, and a 13-36 amino acid unstructured and/or flexible linker. These findings suggest a simple, integrated model for the mechanism of involvement of α in promoter recognition and transcriptional activation.

Original languageEnglish (US)
Pages (from-to)197-203
Number of pages7
JournalCurrent Opinion in Genetics and Development
Volume5
Issue number2
DOIs
StatePublished - Apr 1995

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

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