The evolution of adjuvant radiation therapy for early-stage and locally advanced breast cancer

Nisha Ohri, Bruce G. Haffty

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Adjuvant radiation therapy is often delivered after breast cancer surgery, both in the post-lumpectomy and post-mastectomy settings. Standard fractionation whole breast irradiation (SF-WBI), which is typically delivered over 5-7 weeks, was previously considered the standard of care. More recent data has helped to establish hypofractionated whole breast irradiation (HF-WBI), which consists of a 3-4 week regimen, as a new standard of care. This article provides an overview of the major randomized trials that support the routine use of HF-WBI for the majority of patients undergoing breast-conserving surgery for early-stage breast cancer. Newer data on the use of a hypofractionated approach in the post-mastectomy setting, as well as ongoing randomized trials addressing this topic, are also discussed.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalBreast Journal
Volume26
Issue number1
DOIs
StatePublished - Jan 1 2020

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Surgery
  • Oncology

Keywords

  • accelerated partial breast irradiation
  • breast cancer
  • breast-conserving therapy
  • hypofractionation
  • lumpectomy
  • post-mastectomy radiation
  • standard fractionation

Fingerprint

Dive into the research topics of 'The evolution of adjuvant radiation therapy for early-stage and locally advanced breast cancer'. Together they form a unique fingerprint.

Cite this