The evolution of drug resistance in Mycobacterium tuberculosis: From a mono-rifampin-resistant cluster into increasingly multidrug-resistant variants in an HIV-seropositive population

Pablo Bifani; Barun Mathema; Natalia Kurepina; Elena Shashkina; Julie Bertout; Anne Sophie Blanchis; Soraya Moghazeh; Jeffrey Driscoll; Brigitte Gicquel; Richard Frothingham; Barry N. Kreiswirth

doi:10.1086/588822

The evolution of drug resistance in Mycobacterium tuberculosis: From a mono-rifampin-resistant cluster into increasingly multidrug-resistant variants in an HIV-seropositive population

Pablo Bifani, Barun Mathema, Natalia Kurepina, Elena Shashkina, Julie Bertout, Anne Sophie Blanchis, Soraya Moghazeh, Jeffrey Driscoll, Brigitte Gicquel, Richard Frothingham, Barry N. Kreiswirth

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

We describe the genotypic and phenotypic characteristics of a mono-rifampin-resistant (RIF^R) Mycobacterium tuberculosis strain cluster (designated AU-RIF^R) and the acquisition of additional drug resistance. Drug susceptibility, sequences of regions that determine drug resistance, and basic clinical data were examined. A rare codon duplication (514^TTC) in rpoB conferring high levels of RIF^R (minimum inhibitory concentration of >256 μg/mL) in 29 isolates was identified. AU-RIF^R strains developed secondary resistance to isoniazid and 7 resistance combinations to 6 different antibiotics. Patients infected with AU-RIF^R strains were primarily immunocompromised. These data suggest that host factors, such as HIV status, may allow dissemination of mono-RIF ^R strains and facilitate the accumulation of additional drug resistance.

Original language	English (US)
Pages (from-to)	90-94
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	198
Issue number	1
DOIs	https://doi.org/10.1086/588822
State	Published - Jul 1 2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine

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10.1086/588822

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Bifani, P., Mathema, B., Kurepina, N., Shashkina, E., Bertout, J., Blanchis, A. S., Moghazeh, S., Driscoll, J., Gicquel, B., Frothingham, R., & Kreiswirth, B. N. (2008). The evolution of drug resistance in Mycobacterium tuberculosis: From a mono-rifampin-resistant cluster into increasingly multidrug-resistant variants in an HIV-seropositive population. Journal of Infectious Diseases, 198(1), 90-94. https://doi.org/10.1086/588822

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title = "The evolution of drug resistance in Mycobacterium tuberculosis: From a mono-rifampin-resistant cluster into increasingly multidrug-resistant variants in an HIV-seropositive population",

abstract = "We describe the genotypic and phenotypic characteristics of a mono-rifampin-resistant (RIFR) Mycobacterium tuberculosis strain cluster (designated AU-RIFR) and the acquisition of additional drug resistance. Drug susceptibility, sequences of regions that determine drug resistance, and basic clinical data were examined. A rare codon duplication (514TTC) in rpoB conferring high levels of RIFR (minimum inhibitory concentration of >256 μg/mL) in 29 isolates was identified. AU-RIFR strains developed secondary resistance to isoniazid and 7 resistance combinations to 6 different antibiotics. Patients infected with AU-RIFR strains were primarily immunocompromised. These data suggest that host factors, such as HIV status, may allow dissemination of mono-RIF R strains and facilitate the accumulation of additional drug resistance.",

author = "Pablo Bifani and Barun Mathema and Natalia Kurepina and Elena Shashkina and Julie Bertout and Blanchis, {Anne Sophie} and Soraya Moghazeh and Jeffrey Driscoll and Brigitte Gicquel and Richard Frothingham and Kreiswirth, {Barry N.}",

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Bifani, P, Mathema, B, Kurepina, N, Shashkina, E, Bertout, J, Blanchis, AS, Moghazeh, S, Driscoll, J, Gicquel, B, Frothingham, R & Kreiswirth, BN 2008, 'The evolution of drug resistance in Mycobacterium tuberculosis: From a mono-rifampin-resistant cluster into increasingly multidrug-resistant variants in an HIV-seropositive population', Journal of Infectious Diseases, vol. 198, no. 1, pp. 90-94. https://doi.org/10.1086/588822

The evolution of drug resistance in Mycobacterium tuberculosis: From a mono-rifampin-resistant cluster into increasingly multidrug-resistant variants in an HIV-seropositive population. / Bifani, Pablo; Mathema, Barun; Kurepina, Natalia et al.
In: Journal of Infectious Diseases, Vol. 198, No. 1, 01.07.2008, p. 90-94.

Research output: Contribution to journal › Article › peer-review

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AU - Shashkina, Elena

AU - Bertout, Julie

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AU - Moghazeh, Soraya

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AU - Kreiswirth, Barry N.

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The evolution of drug resistance in Mycobacterium tuberculosis: From a mono-rifampin-resistant cluster into increasingly multidrug-resistant variants in an HIV-seropositive population

Abstract

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