TY - JOUR
T1 - The evolution of drug resistance in Mycobacterium tuberculosis
T2 - From a mono-rifampin-resistant cluster into increasingly multidrug-resistant variants in an HIV-seropositive population
AU - Bifani, Pablo
AU - Mathema, Barun
AU - Kurepina, Natalia
AU - Shashkina, Elena
AU - Bertout, Julie
AU - Blanchis, Anne Sophie
AU - Moghazeh, Soraya
AU - Driscoll, Jeffrey
AU - Gicquel, Brigitte
AU - Frothingham, Richard
AU - Kreiswirth, Barry N.
PY - 2008/7/1
Y1 - 2008/7/1
N2 - We describe the genotypic and phenotypic characteristics of a mono-rifampin-resistant (RIFR) Mycobacterium tuberculosis strain cluster (designated AU-RIFR) and the acquisition of additional drug resistance. Drug susceptibility, sequences of regions that determine drug resistance, and basic clinical data were examined. A rare codon duplication (514TTC) in rpoB conferring high levels of RIFR (minimum inhibitory concentration of >256 μg/mL) in 29 isolates was identified. AU-RIFR strains developed secondary resistance to isoniazid and 7 resistance combinations to 6 different antibiotics. Patients infected with AU-RIFR strains were primarily immunocompromised. These data suggest that host factors, such as HIV status, may allow dissemination of mono-RIF R strains and facilitate the accumulation of additional drug resistance.
AB - We describe the genotypic and phenotypic characteristics of a mono-rifampin-resistant (RIFR) Mycobacterium tuberculosis strain cluster (designated AU-RIFR) and the acquisition of additional drug resistance. Drug susceptibility, sequences of regions that determine drug resistance, and basic clinical data were examined. A rare codon duplication (514TTC) in rpoB conferring high levels of RIFR (minimum inhibitory concentration of >256 μg/mL) in 29 isolates was identified. AU-RIFR strains developed secondary resistance to isoniazid and 7 resistance combinations to 6 different antibiotics. Patients infected with AU-RIFR strains were primarily immunocompromised. These data suggest that host factors, such as HIV status, may allow dissemination of mono-RIF R strains and facilitate the accumulation of additional drug resistance.
UR - http://www.scopus.com/inward/record.url?scp=46349091974&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=46349091974&partnerID=8YFLogxK
U2 - 10.1086/588822
DO - 10.1086/588822
M3 - Article
C2 - 18498237
AN - SCOPUS:46349091974
SN - 0022-1899
VL - 198
SP - 90
EP - 94
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -