The evolution of drug resistance in Mycobacterium tuberculosis: From a mono-rifampin-resistant cluster into increasingly multidrug-resistant variants in an HIV-seropositive population

Pablo Bifani, Barun Mathema, Natalia Kurepina, Elena Shashkina, Julie Bertout, Anne Sophie Blanchis, Soraya Moghazeh, Jeffrey Driscoll, Brigitte Gicquel, Richard Frothingham, Barry N. Kreiswirth

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

We describe the genotypic and phenotypic characteristics of a mono-rifampin-resistant (RIFR) Mycobacterium tuberculosis strain cluster (designated AU-RIFR) and the acquisition of additional drug resistance. Drug susceptibility, sequences of regions that determine drug resistance, and basic clinical data were examined. A rare codon duplication (514TTC) in rpoB conferring high levels of RIFR (minimum inhibitory concentration of >256 μg/mL) in 29 isolates was identified. AU-RIFR strains developed secondary resistance to isoniazid and 7 resistance combinations to 6 different antibiotics. Patients infected with AU-RIFR strains were primarily immunocompromised. These data suggest that host factors, such as HIV status, may allow dissemination of mono-RIF R strains and facilitate the accumulation of additional drug resistance.

Original languageEnglish (US)
Pages (from-to)90-94
Number of pages5
JournalJournal of Infectious Diseases
Volume198
Issue number1
DOIs
StatePublished - Jul 1 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

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