The evolution of the RCSB Protein Data Bank website

Philip E. Bourne, Bojan Beran, Chunxiao Bi, Wolfgang F. Bluhm, Dimitris Dimitropoulos, Zukang Feng, David S. Goodsell, Andreas Prlić, Gregory B. Quinn, Peter W. Rose, John Westbrook, Benjamin Yukich, Jasmine Young, Christine Zardecki, Helen M. Berman

Research output: Contribution to journalArticle

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The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) supports scientific research and education by providing an essential resource of information about biomolecular structures. As a member of the Worldwide Protein Data Bank (wwPDB), the RCSB PDB curates and annotates the data about the experimentally determined three-dimensional structures of proteins and nucleic acids that are deposited into the PDB archive. The RCSB PDB also provides online resources to access the data in the archive, including a relational database supporting simple and complex query and reporting, visualization tools, structure-sequence comparison tools, access to the associated literature, and educational services. In the 11 years (1999-2010) since RCSB PDB has been in operation, the amount of data in the archive has increased six-fold, along with an increase in the complexity of structures being determined and in the number of experimental methods used. The evolution required by RCSB PDB to meet these challenges provides insight into the motivation and challenges of developing and maintaining a major biological resource, particularly the one used in understanding the molecular details of living systems in both normal and disease states.

Original languageEnglish (US)
Pages (from-to)782-789
Number of pages8
JournalWiley Interdisciplinary Reviews: Computational Molecular Science
Issue number5
StatePublished - Sep 1 2011


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Computational Mathematics
  • Materials Chemistry

Cite this

Bourne, P. E., Beran, B., Bi, C., Bluhm, W. F., Dimitropoulos, D., Feng, Z., Goodsell, D. S., Prlić, A., Quinn, G. B., Rose, P. W., Westbrook, J., Yukich, B., Young, J., Zardecki, C., & Berman, H. M. (2011). The evolution of the RCSB Protein Data Bank website. Wiley Interdisciplinary Reviews: Computational Molecular Science, 1(5), 782-789.