The first determination of DNA sequence of a specific gene

Research output: Contribution to journalLetter

Abstract

How and when the first DNA sequence of a gene was determined? In 1977, F. Sanger came up with an innovative technology to sequence DNA by using chain terminators, and determined the entire DNA sequence of the 5375-base genome of bacteriophage φX 174 (Sanger et al., 1977). While this Sanger's achievement has been recognized as the first DNA sequencing of genes, we had determined DNA sequence of a gene, albeit a partial sequence, 11 years before the Sanger's DNA sequence (Okada et al., 1966).

Original languageEnglish (US)
Pages (from-to)94-95
Number of pages2
JournalGene
Volume582
Issue number1
DOIs
StatePublished - May 10 2016

Fingerprint

DNA Sequence Analysis
Genes
Bacteriophages
Genome
Technology

All Science Journal Classification (ASJC) codes

  • Genetics

Keywords

  • First DNA sequencing
  • Frame-shift mutations
  • Sanger
  • T4 phage

Cite this

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abstract = "How and when the first DNA sequence of a gene was determined? In 1977, F. Sanger came up with an innovative technology to sequence DNA by using chain terminators, and determined the entire DNA sequence of the 5375-base genome of bacteriophage φX 174 (Sanger et al., 1977). While this Sanger's achievement has been recognized as the first DNA sequencing of genes, we had determined DNA sequence of a gene, albeit a partial sequence, 11 years before the Sanger's DNA sequence (Okada et al., 1966).",
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The first determination of DNA sequence of a specific gene. / Inouye, Masayori.

In: Gene, Vol. 582, No. 1, 10.05.2016, p. 94-95.

Research output: Contribution to journalLetter

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