The first determination of DNA sequence of a specific gene

Research output: Contribution to journalLetter


How and when the first DNA sequence of a gene was determined? In 1977, F. Sanger came up with an innovative technology to sequence DNA by using chain terminators, and determined the entire DNA sequence of the 5375-base genome of bacteriophage φX 174 (Sanger et al., 1977). While this Sanger's achievement has been recognized as the first DNA sequencing of genes, we had determined DNA sequence of a gene, albeit a partial sequence, 11 years before the Sanger's DNA sequence (Okada et al., 1966).

Original languageEnglish (US)
Pages (from-to)94-95
Number of pages2
Issue number1
StatePublished - May 10 2016

All Science Journal Classification (ASJC) codes

  • Genetics


  • First DNA sequencing
  • Frame-shift mutations
  • Sanger
  • T4 phage

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