TY - JOUR
T1 - The genetics of dopa decarboxylase in Drosophila melanogaster - V. Ddc and 1(2)amd alleles
T2 - Isolation, characterization and intragenic complementation
AU - Wright, Theodore R.F.
AU - Black, Bruce C.
AU - Bishop, Clifton P.
AU - Marsh, J. Lawrence
AU - Pentz, Ellen S.
AU - Steward, Ruth
AU - Wright, Eileen Y.
PY - 1982/11
Y1 - 1982/11
N2 - Data on 46 mutations in the structural gene, Ddc. for dopa decarboxylase and 33 mutations in the αmethyl dopa hypersensitive gene, 1(2)amd, in Drosophila melanogaster are presented including information on their isolation, their effects on DDC activity, and their sensitivity to dietary αmethyl dopa. Intragenic complementation of both loci is documented, the effects of heteroallelic complementing heterozygosity on DDC activity, in vitro thermolability of DDC, and on temperature sensitive viability are presented. Data are marshalled to support rejection of the hypothesis that Ddc mutations and 1(2)amd, mutations are lesions in a single gene.
AB - Data on 46 mutations in the structural gene, Ddc. for dopa decarboxylase and 33 mutations in the αmethyl dopa hypersensitive gene, 1(2)amd, in Drosophila melanogaster are presented including information on their isolation, their effects on DDC activity, and their sensitivity to dietary αmethyl dopa. Intragenic complementation of both loci is documented, the effects of heteroallelic complementing heterozygosity on DDC activity, in vitro thermolability of DDC, and on temperature sensitive viability are presented. Data are marshalled to support rejection of the hypothesis that Ddc mutations and 1(2)amd, mutations are lesions in a single gene.
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U2 - 10.1007/BF00332991
DO - 10.1007/BF00332991
M3 - Article
AN - SCOPUS:0001912929
SN - 1617-4615
VL - 188
SP - 18
EP - 26
JO - Zeitschrift für Induktive Abstammungs- und Vererbungslehre
JF - Zeitschrift für Induktive Abstammungs- und Vererbungslehre
IS - 1
ER -