The genetics of dopa decarboxylase in Drosophila melanogaster - V. Ddc and 1(2)amd alleles: Isolation, characterization and intragenic complementation

Theodore R.F. Wright; Bruce C. Black; Clifton P. Bishop; J. Lawrence Marsh; Ellen S. Pentz; Ruth Steward; Eileen Y. Wright

doi:10.1007/BF00332991

The genetics of dopa decarboxylase in Drosophila melanogaster - V. Ddc and 1(2)amd alleles: Isolation, characterization and intragenic complementation

Theodore R.F. Wright, Bruce C. Black, Clifton P. Bishop, J. Lawrence Marsh, Ellen S. Pentz, Ruth Steward, Eileen Y. Wright

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Abstract

Data on 46 mutations in the structural gene, Ddc. for dopa decarboxylase and 33 mutations in the αmethyl dopa hypersensitive gene, 1(2)amd, in Drosophila melanogaster are presented including information on their isolation, their effects on DDC activity, and their sensitivity to dietary αmethyl dopa. Intragenic complementation of both loci is documented, the effects of heteroallelic complementing heterozygosity on DDC activity, in vitro thermolability of DDC, and on temperature sensitive viability are presented. Data are marshalled to support rejection of the hypothesis that Ddc mutations and 1(2)amd, mutations are lesions in a single gene.

Original language	English (US)
Pages (from-to)	18-26
Number of pages	9
Journal	Mgg Molecular & General Genetics
Volume	188
Issue number	1
DOIs	https://doi.org/10.1007/BF00332991
State	Published - Nov 1982
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics

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10.1007/BF00332991

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title = "The genetics of dopa decarboxylase in Drosophila melanogaster - V. Ddc and 1(2)amd alleles: Isolation, characterization and intragenic complementation",

abstract = "Data on 46 mutations in the structural gene, Ddc. for dopa decarboxylase and 33 mutations in the αmethyl dopa hypersensitive gene, 1(2)amd, in Drosophila melanogaster are presented including information on their isolation, their effects on DDC activity, and their sensitivity to dietary αmethyl dopa. Intragenic complementation of both loci is documented, the effects of heteroallelic complementing heterozygosity on DDC activity, in vitro thermolability of DDC, and on temperature sensitive viability are presented. Data are marshalled to support rejection of the hypothesis that Ddc mutations and 1(2)amd, mutations are lesions in a single gene.",

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T1 - The genetics of dopa decarboxylase in Drosophila melanogaster - V. Ddc and 1(2)amd alleles

T2 - Isolation, characterization and intragenic complementation

AU - Wright, Theodore R.F.

AU - Black, Bruce C.

AU - Bishop, Clifton P.

AU - Marsh, J. Lawrence

AU - Pentz, Ellen S.

AU - Steward, Ruth

AU - Wright, Eileen Y.

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N2 - Data on 46 mutations in the structural gene, Ddc. for dopa decarboxylase and 33 mutations in the αmethyl dopa hypersensitive gene, 1(2)amd, in Drosophila melanogaster are presented including information on their isolation, their effects on DDC activity, and their sensitivity to dietary αmethyl dopa. Intragenic complementation of both loci is documented, the effects of heteroallelic complementing heterozygosity on DDC activity, in vitro thermolability of DDC, and on temperature sensitive viability are presented. Data are marshalled to support rejection of the hypothesis that Ddc mutations and 1(2)amd, mutations are lesions in a single gene.

AB - Data on 46 mutations in the structural gene, Ddc. for dopa decarboxylase and 33 mutations in the αmethyl dopa hypersensitive gene, 1(2)amd, in Drosophila melanogaster are presented including information on their isolation, their effects on DDC activity, and their sensitivity to dietary αmethyl dopa. Intragenic complementation of both loci is documented, the effects of heteroallelic complementing heterozygosity on DDC activity, in vitro thermolability of DDC, and on temperature sensitive viability are presented. Data are marshalled to support rejection of the hypothesis that Ddc mutations and 1(2)amd, mutations are lesions in a single gene.

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The genetics of dopa decarboxylase in Drosophila melanogaster - V. Ddc and 1(2)amd alleles: Isolation, characterization and intragenic complementation

Abstract

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